Hadjicharalambous Marina R, Lindsay Mark A
Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Noncoding RNA. 2019 Apr 19;5(2):34. doi: 10.3390/ncrna5020034.
Innate immunity provides the initial defence against infection and it is now clear that long non-coding RNAs (lncRNAs) are important regulators of this response. Following activation of the innate response, we commonly see rapid induction of these lncRNAs and this is often mediated via the pro-inflammatory transcription factor, nuclear factor-κB (NF-κB). Knockdown studies have shown that lncRNAs tend to act in trans to regulate the expression of multiple inflammatory mediators and other responses. Mechanistically, many lncRNAs have demonstrated acting through heterogeneous nuclear ribonucleoproteins, complexes that are implicated chromatin re-modelling, transcription process and translation. In addition, these lncRNAs have also been shown to interact with multiple other proteins involved in the regulation of chromatin re-modelling, as well as those proteins involved in intracellular immune signalling, which include NF-κB. In this review, we will describe the evidence that supports this emerging role of lncRNA in the innate immune response.
固有免疫提供了针对感染的初始防御，现在很清楚的是，长链非编码RNA（lncRNA）是这种反应的重要调节因子。在固有免疫反应激活后，我们通常会看到这些lncRNA的快速诱导，这通常是通过促炎转录因子核因子-κB（NF-κB）介导的。敲低研究表明，lncRNA倾向于通过反式作用来调节多种炎症介质的表达和其他反应。从机制上讲，许多lncRNA已被证明通过异质性核核糖核蛋白起作用，这些复合物与染色质重塑、转录过程和翻译有关。此外，这些lncRNA还被证明与参与染色质重塑调节的多种其他蛋白质以及参与细胞内免疫信号传导的蛋白质相互作用，其中包括NF-κB。在这篇综述中，我们将描述支持lncRNA在固有免疫反应中这一新兴作用的证据。
