Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany.
Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany
J Exp Med. 2019 Jun 3;216(6):1234-1243. doi: 10.1084/jem.20181739. Epub 2019 Apr 25.
A link between chronic inflammation and development of tumors is well established. Moreover, it has become evident that tumorigenesis is not a cell autonomous disease, and an inflammatory microenvironment is a prerequisite of basically all tumors, including those that emerge in the absence of overt inflammation. This knowledge has led to the development of anti-inflammatory concepts to treat and prevent cancer. In contrast, immunotherapies, in particular checkpoint inhibitors, representing the most significant progress in the therapy of several malignancies depend on the presence of a pro-inflammatory "hot" environment. Here, we discuss pro- and anti-inflammatory concepts for the treatment of cancer.
慢性炎症与肿瘤发展之间存在关联，这一点已得到充分证实。此外，肿瘤发生并非是一种细胞自主性疾病，炎症微环境是包括那些在没有明显炎症的情况下出现的肿瘤的基本前提。这一认识促使人们开发出抗炎概念来治疗和预防癌症。相比之下，免疫疗法，特别是检查点抑制剂，代表了几种恶性肿瘤治疗方面的重大进展，取决于是否存在促炎的“热”环境。在这里，我们讨论了用于癌症治疗的抗炎和促炎概念。
