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氧化锌和氧化铝纳米颗粒对结肠癌细胞抗增殖潜力的比较研究

Comparative study on anti-proliferative potentials of zinc oxide and aluminium oxide nanoparticles in colon cancer cells.

作者信息

Subramaniam Vimala Devi, Ramachandran Murugesan, Marotta Francesco, Banerjee Antara, Sun Xiao Feng, Pathak Surajit

机构信息

Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai-603103, India.

ReGenera R&D International for Aging Intervention, Milan and Beijing, China-Italy

出版信息

Acta Biomed. 2019 May 23;90(2):241-247. doi: 10.23750/abm.v90i2.6939.

DOI:10.23750/abm.v90i2.6939
PMID:31125002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6776199/
Abstract

BACKGROUND AND AIM OF THE STUDY

Use of commercial products containing nanoparticles formulated from zinc oxide (ZnO) and aluminium oxide (Al2O-3) has increased significantly. These nanoparticles are widely used as ingredient in cosmetics, and also in food packaging industry although their toxicity status is yet to be studied. Here, we aimed to explore the effect of zinc oxide nanoparticles (ZnO-NPs) and aluminium oxide nanoparticles (ANPs) in human HT29 colon cancer cell line.

METHODS

In this study, ZnO-NPs were synthesized by chemical method and ANPs synthesized by sol-gel method and were characterized using UV-Vis spectroscopy, X ray diffraction and Transmittance electron microscopy. The effects of ZnO-NPs and ANPs was determined by cell viability, membrane integrity and colony formation potentials.

RESULTS

ZnO-NPs and ANPs inhibit HT29, colon cancer cell proliferation in a dose dependent manner, and affect the membrane potentials and also prevent the colony formation.

CONCLUSIONS

The results suggest that ZnO NPs are found to be more effective than ANPs in reducing colon cancer cell proliferation.

摘要

研究背景与目的

含有由氧化锌（ZnO）和氧化铝（Al2O-3）制成的纳米颗粒的商业产品的使用显著增加。这些纳米颗粒被广泛用作化妆品成分，也用于食品包装行业，尽管它们的毒性状况尚待研究。在此，我们旨在探讨氧化锌纳米颗粒（ZnO-NPs）和氧化铝纳米颗粒（ANPs）对人HT29结肠癌细胞系的影响。

方法

在本研究中，ZnO-NPs通过化学方法合成，ANPs通过溶胶-凝胶法合成，并使用紫外-可见光谱、X射线衍射和透射电子显微镜进行表征。通过细胞活力、膜完整性和集落形成潜力来确定ZnO-NPs和ANPs的作用。

结果

ZnO-NPs和ANPs以剂量依赖性方式抑制HT29结肠癌细胞增殖，并影响膜电位，还能阻止集落形成。

结论

结果表明，在减少结肠癌细胞增殖方面，ZnO NPs比ANPs更有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/a9eaef3b6b7b/ACTA-90-241-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/34874be41295/ACTA-90-241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/b18c9b9c1513/ACTA-90-241-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/fb16a40adeb2/ACTA-90-241-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/20229f943f2b/ACTA-90-241-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/564835306381/ACTA-90-241-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/f8ac47975aae/ACTA-90-241-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/a9eaef3b6b7b/ACTA-90-241-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/34874be41295/ACTA-90-241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/b18c9b9c1513/ACTA-90-241-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/fb16a40adeb2/ACTA-90-241-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/20229f943f2b/ACTA-90-241-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/564835306381/ACTA-90-241-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/f8ac47975aae/ACTA-90-241-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65b9/6776199/a9eaef3b6b7b/ACTA-90-241-g007.jpg

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2
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Nanomaterials (Basel). 2015 Jun 9;5(2):1004-1021. doi: 10.3390/nano5021004.
3
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无机金属纳米颗粒在衰老及衰老相关疾病中的生物医学应用。
J Adv Res. 2025 May;71:551-570. doi: 10.1016/j.jare.2024.05.023. Epub 2024 May 29.
4
Metal-based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy.金属基纳米材料和纳米复合材料作为癌症化疗中前景广阔的前沿领域。
MedComm (2020). 2023 Apr 4;4(2):e253. doi: 10.1002/mco2.253. eCollection 2023 Apr.
5
MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework.“同一个健康”框架下耐甲氧西林金黄色葡萄球菌的流行病学、传播、病理生理学、治疗及预防概要
Front Microbiol. 2023 Jan 10;13:1067284. doi: 10.3389/fmicb.2022.1067284. eCollection 2022.
6
Optimization of Tumor Targeting Gold Nanoparticles for Glioblastoma Applications.用于胶质母细胞瘤应用的肿瘤靶向金纳米颗粒的优化
Nanomaterials (Basel). 2022 Nov 2;12(21):3869. doi: 10.3390/nano12213869.
7
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Nanomaterials (Basel). 2022 Jul 30;12(15):2635. doi: 10.3390/nano12152635.
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4
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6
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7
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Nanomedicine. 2011 Dec;7(6):904-13. doi: 10.1016/j.nano.2011.04.011. Epub 2011 May 19.
8
Inorganic nanoparticles in cancer therapy.癌症治疗中的无机纳米颗粒。
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9
Preferential killing of cancer cells and activated human T cells using ZnO nanoparticles.使用氧化锌纳米颗粒对癌细胞和活化的人T细胞进行选择性杀伤。
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10
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