长链非编码RNA-MIAT在冠状动脉粥样硬化性心脏病患者中表达升高。
LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease.
作者信息
Tan Jin, Liu Shengzhong, Jiang Qin, Yu Tao, Huang Keli
机构信息
Cardiovascular Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610000, China.
出版信息
Cardiol Res Pract. 2019 Apr 16;2019:6280194. doi: 10.1155/2019/6280194. eCollection 2019.
BACKGROUND
To study the expression and clinical significance of long noncoding RNA- (lncRNA-) MIAT in patients with coronary atherosclerotic heart disease (CAD).
METHODS
Serum MIAT, interleukin-6 (IL-6), and tumor necrosis factor- (TNF-) in 106 CAD patients and 89 healthy donors were detected. Correlations between serum MIAT and serum IL-6 and TNF- were analyzed. Risk factors for patients with CAD were analyzed by multiple factor analysis.
RESULTS
Compared with healthy donors, serum lncRNA-MIAT was significantly increased in CAD patients. Serum MIAT was positively correlated with serum IL-6 and TNF- in CAD. Multivariate analysis found that hypertension (OR (95% CI) = 3.471 (2.180-4.091), =0.011), diabetes (OR (95% CI) = 3.682 (1.698-4.897), =0.003), HDL-C (OR (95% CI) = 3.372 (1.760-6.920), =0.001), and serum MIAT expression (OR (95% CI) = 2.687 (1.683-7.468), =0.001) were independent risk factors for CAD.
CONCLUSIONS
Serum lncRNA-MIAT in CAD patients was significantly increased, which may be a potential marker for diagnosis and prognosis of CAD.
背景
研究长链非编码RNA-（lncRNA-）心肌梗死相关转录本（MIAT）在冠状动脉粥样硬化性心脏病（CAD）患者中的表达及临床意义。
方法
检测106例CAD患者和89例健康供者血清中的MIAT、白细胞介素-6（IL-6）和肿瘤坏死因子-（TNF-）。分析血清MIAT与血清IL-6和TNF-之间的相关性。采用多因素分析CAD患者的危险因素。
结果
与健康供者相比，CAD患者血清lncRNA-MIAT显著升高。CAD患者血清MIAT与血清IL-6和TNF-呈正相关。多因素分析发现高血压（比值比（OR）（95%可信区间）=3.471（2.180-4.091），P=0.011）、糖尿病（OR（95%可信区间）=3.682（1.698-4.897），P=0.003）、高密度脂蛋白胆固醇（HDL-C）（OR（95%可信区间）=3.372（1.760-6.920），P=0.001）和血清MIAT表达（OR（95%可信区间）=2.687（1.683-7.468），P=0.001）是CAD的独立危险因素。
结论
CAD患者血清lncRNA-MIAT显著升高，可能是CAD诊断和预后的潜在标志物。
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