三维打印具有水平孔隙和组成梯度的组织工程支架。
Three-Dimensional Printing of Tissue Engineering Scaffolds with Horizontal Pore and Composition Gradients.
机构信息
1Department of Bioengineering, BioScience Research Collaborative, Rice University, Houston, Texas.
2Biomaterials Laboratory, Rice University, Houston, Texas.
出版信息
Tissue Eng Part C Methods. 2019 Jul;25(7):411-420. doi: 10.1089/ten.TEC.2019.0112.
Abstract
In this study, we report the development of a novel multimaterial segmented three-dimensional printing methodology to fabricate porous scaffolds containing discrete horizontal gradients of composition and porosity. This methodology is particularly beneficial to preparing porous scaffolds with intricate structures and graded compositions for the regeneration of complex tissues. The technique presented is compatible with many commercially available bioprinters commonly used in biofabrication, and can be adapted to better replicate the architectural and compositional requirements of individual tissues compared with traditional scaffold printing methods.
摘要
在这项研究中，我们报告了一种新型的多材料分段三维打印方法的开发，用于制造含有离散水平组成和孔隙率梯度的多孔支架。这种方法特别有利于制备具有复杂结构和梯度组成的多孔支架，用于复杂组织的再生。所提出的技术与许多商业上可获得的生物打印机兼容，通常用于生物制造，并且可以与传统的支架打印方法相比，更好地复制单个组织的结构和组成要求。
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