Histocompatibility Laboratory, Specialty Hospital, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.
Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico. Electronic address: http://www.shh.mpg.de/en.
Hum Immunol. 2020 Sep;81(9):475-477. doi: 10.1016/j.humimm.2019.06.007. Epub 2019 Jun 11.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes for the Baja California region include nine Native American and five European haplotypes. Admixture estimates revealed that the main genetic components are European (50.45 ± 1.84% by ML; 42.03% of European haplotypes) and Native American (43.72 ± 2.36% by ML; 40.24% of Native American haplotypes), while the African genetic component was less apparent (5.83 ± 0.98% by ML; 9.36% of African haplotypes).
我们通过 PCR-SSP 基于分型的方法，对来自下加利福尼亚州北部和南部生活在墨西卡利（N=100）、拉巴斯（N=75）、蒂华纳（N=25）和农村社区（N=50）的 250 名墨西哥人进行了 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因研究，以获得有关等位基因和单倍型频率的信息。下加利福尼亚地区最常见的单倍型包括 9 个美洲原住民和 5 个欧洲单倍型。混合估计显示，主要的遗传成分是欧洲（最大似然法[ML]为 50.45±1.84%；欧洲单倍型占 42.03%）和美洲原住民（ML 为 43.72±2.36%；美洲原住民单倍型占 40.24%），而非洲遗传成分则不那么明显（ML 为 5.83±0.98%；非洲单倍型占 9.36%）。
