Zhou Liyuan, Xiao Xinhua, Zhang Qian, Zheng Jia, Deng Mingqun
Key Laboratory of Endocrinology, Department of Endocrinology, Translational Medicine Center, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Ministry of Health, Beijing, China.
Front Endocrinol (Lausanne). 2019 Jun 27;10:413. doi: 10.3389/fendo.2019.00413. eCollection 2019.
Excessive white adipose tissue (WAT) accumulation due to an imbalance between caloric intake and energy expenditure (EE) characterizes obesity. However, brown adipose tissue (BAT) is highly specialized for the dissipation of energy. Recent evidence indicated that the activation of BAT and the induction of WAT browning might be promising approaches to combat obesity by increasing EE and regulating glucose and lipid metabolism. Resveratrol, which is a polyphenolic compound, has been widely acknowledged to have protective effects against obesity and related metabolic disorders. The induction of WAT browning has been considered as one of the crucial factors in the metabolic benefits of resveratrol. Nevertheless, the specific mechanism that is involved is largely unclear. As a prebiotic-like polyphenol, resveratrol is able to modulate the composition of gut microbiota. In addition, in recent years, the impact of gut microbiota on the browning of WAT has received increasing attention and has been initially confirmed to play a role. By considering all these factors, this review explores the potential link between dietary resveratrol and the browning of WAT, which may be modulated by gut microbiota and their metabolites and proposes the "gut microbiota- adipose tissue" axis plays a vital role in the anti-obesity effects of resveratrol. This observation might provide novel insights and targets that could be used for fighting against obesity and associated metabolic disorders.
热量摄入与能量消耗（EE）之间的失衡导致白色脂肪组织（WAT）过度积累是肥胖的特征。然而，棕色脂肪组织（BAT）专门用于能量消耗。最近的证据表明，激活BAT和诱导WAT褐变可能是通过增加EE以及调节葡萄糖和脂质代谢来对抗肥胖的有前景的方法。白藜芦醇是一种多酚化合物，已被广泛认为对肥胖和相关代谢紊乱具有保护作用。WAT褐变的诱导被认为是白藜芦醇代谢益处的关键因素之一。然而，其中涉及的具体机制在很大程度上尚不清楚。作为一种益生元样多酚，白藜芦醇能够调节肠道微生物群的组成。此外，近年来，肠道微生物群对WAT褐变的影响受到越来越多的关注，并已初步证实其发挥作用。综合考虑所有这些因素，本综述探讨了膳食白藜芦醇与WAT褐变之间的潜在联系，这种联系可能受肠道微生物群及其代谢产物的调节，并提出“肠道微生物群-脂肪组织”轴在白藜芦醇的抗肥胖作用中起着至关重要的作用。这一观察结果可能为对抗肥胖及相关代谢紊乱提供新的见解和靶点。
