Roi Alexandra, Ardelean Lavinia Cosmina, Roi Ciprian Ioan, Boia Eugen-Radu, Boia Simina, Rusu Laura-Cristina
Department of Oral Pathology, "Victor Babes" University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania.
Department of Technology of Materials and Devices in Dental Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu sq, 300041 Timisoara, Romania.
Materials (Basel). 2019 Jul 18;12(14):2296. doi: 10.3390/ma12142296.
The advancements made in biomaterials have an important impact on oral tissue engineering, especially on the bone regeneration process. Currently known as the gold standard in bone regeneration, grafting procedures can sometimes be successfully replaced by a biomaterial scaffold with proper characteristics. Whether natural or synthetic polymers, biomaterials can serve as potential scaffolds with major influences on cell adhesion, proliferation and differentiation. Continuous research has enabled the development of scaffolds that can be specifically designed to replace the targeted tissue through changes in their surface characteristics and the addition of growth factors and biomolecules. The progress in tissue engineering is incontestable and research shows promising contributions to the further development of this field. The present review aims to outline the progress in oral tissue engineering, the advantages of biomaterial scaffolds, their direct implication in the osteogenic process and future research directions.
生物材料领域取得的进展对口腔组织工程具有重要影响，尤其是对骨再生过程。目前，移植手术被认为是骨再生的金标准，但有时具有适当特性的生物材料支架可以成功替代移植手术。无论是天然聚合物还是合成聚合物，生物材料都可以作为潜在的支架，对细胞黏附、增殖和分化产生重大影响。持续的研究已促成了支架的开发，这些支架可以通过改变其表面特性以及添加生长因子和生物分子来专门设计，以替代目标组织。组织工程的进展是无可争议的，研究表明该领域的进一步发展前景广阔。本综述旨在概述口腔组织工程的进展、生物材料支架的优势、它们在成骨过程中的直接作用以及未来的研究方向。
