Department of Chemistry and the Texas Center for Superconductivity, University of Houston, Houston, TX 77204, USA.
Int J Mol Sci. 2019 Jul 12;20(14):3422. doi: 10.3390/ijms20143422.
A "smart" core@shell composite nanoparticle (NP) having dual-response mechanisms (i.e., temperature and light) was synthesized, and its efficacy in the loading and release of small molecules was explored. These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesoporous (-) silica layer (-SiO). The GNS@-SiO nanoparticles are further encapsulated within a thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel (PNIPAM-co-AA). The multi-responsive composite NPs were designed to create thermally and optically modulated drug-delivery vehicles with a -SiO layer providing additional non-collapsible space for drug storage. The influence of the -SiO layer on the efficacy of loading and release of methylene blue, which serves as a model for a small-molecule therapeutic drug, was evaluated. The "smart" core@shell composite NPs having a -SiO layer demonstrated an improved capacity to load and release small molecules compared to the corresponding NPs with no -SiO shell. Additionally, an efficient response by the composite NPs was successfully induced by the thermal energy generated from the gold nanoshell core upon exposure to near infrared (NIR) stimulation.
一种具有双重响应机制（即温度和光）的“智能”核/壳复合纳米粒子（NP）被合成，并探索了其在小分子的负载和释放方面的效果。这些核/壳 NPs 由光学活性的金纳米壳（GNS）核和介孔（-）硅层（-SiO）组成。GNS@-SiO 纳米粒子进一步被包裹在热响应性聚（N-异丙基丙烯酰胺-co-丙烯酸）水凝胶（PNIPAM-co-AA）中。多响应性复合 NPs 的设计旨在创建热和光调节的药物输送载体，-SiO 层为药物储存提供额外的不可塌陷空间。评估了 -SiO 层对作为小分子治疗药物模型的亚甲蓝的负载和释放效果的影响。与没有 -SiO 壳的相应 NPs 相比，具有 -SiO 层的“智能”核/壳复合 NPs 显示出了提高的负载和释放小分子的能力。此外，复合 NPs 可以通过金纳米壳核在近红外（NIR）刺激下产生的热能，实现有效的响应。
