Unit of Research and Education in Health, Unidad Médica de Alta Especialidad (UMAE) # 10, Instituto Mexicano del Seguro Social (IMSS), Mérida, Yucatán, Mexico.
Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
Hum Immunol. 2020 Sep;81(9):573-575. doi: 10.1016/j.humimm.2019.07.279. Epub 2019 Jul 22.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 98 Mexicans from the state of Quintana Roo living in the city of Cancún (N = 48) and rural communities (N = 50), to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We found that the most frequent haplotypes in Quintana Roo include ten Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Quintana Roo are Native American (80.85 ± 3.70% by ML; 60.20% of Native American haplotypes) and European (15.19 ± 14.25% by ML; 26.02% of European haplotypes), and a less prominent African genetic component (3.96 ± 10.75% by ML; 6.63% of African haplotypes).
我们通过基于 PCR-SSP 的分型方法，对来自墨西哥金塔纳罗奥州的 98 名生活在坎昆市（N=48）和农村社区（N=50）的墨西哥人进行了 HLA I 类（HLA-A、-B）和 II 类（HLA-DRB1、-DQB1）等位基因研究，以获得有关等位基因和单倍型频率及其连锁不平衡的信息。我们发现，金塔纳罗奥州最常见的单倍型包括 10 种美洲原住民和 2 种欧洲单倍型。混合估计表明，金塔纳罗奥州的主要遗传成分是美洲原住民（ML 法的 80.85±3.70%；60.20%的美洲原住民单倍型）和欧洲人（ML 法的 15.19±14.25%；26.02%的欧洲人单倍型），以及不太明显的非洲遗传成分（ML 法的 3.96±10.75%；6.63%的非洲单倍型）。
