Department of Clinical Laboratory, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, China.
School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Biomed Res Int. 2019 Jul 2;2019:4649705. doi: 10.1155/2019/4649705. eCollection 2019.
High cancer mortality is attributed to metastasis to a large extent. However, cancer metastasis remains devoid of dynamic monitoring and early prevention in terms of current advances in diagnostic means and therapeutic modalities. Meanwhile, studies have shown that reciprocal crosstalk among cells via exosomes plays a critical role in maintaining normal physiological state or triggering disease progression, including cancer metastasis. Therefore, in this review, we focus on the latest literature (primarily from 2018) to summarize action mechanisms and experimental studies of exosomes in cancer metastasis and put forward some problems as well as new outlooks of these studies.
高癌症死亡率在很大程度上归因于转移。然而，就目前的诊断手段和治疗方式的进展而言，癌症转移仍然缺乏动态监测和早期预防。同时，研究表明，细胞通过外泌体的相互交流在维持正常生理状态或引发疾病进展（包括癌症转移）方面起着关键作用。因此，在这篇综述中，我们主要关注 2018 年以来的最新文献，总结外泌体在癌症转移中的作用机制和实验研究，并提出这些研究的一些问题和新展望。
