College of Life Sciences of Shanxi Agricultural University , Taigu , China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University , Beijing , China.
GM Crops Food. 2019;10(3):181-190. doi: 10.1080/21645698.2019.1649565. Epub 2019 Jul 31.
Glyphosate tolerant soybeans represent a large portion of soybeans grown and fed to farm animals around the world. Despite their widespread use for many years, some have raised questions regarding their safety because the soybeans were genetically modified. The CP4 EPSPS gene which imparts resistance to topical application of the herbicide glyphosate was introduced into soybeans. Application of glyphosate to soybean fields will reduce weed pressure and increase soybean yield. To assess their safety on the rat reproduction system, male Sprague Dawley rats were fed either glyphosate-tolerant (GM) soybean (40-3-2) or near-isogenic, non-GM (A5403) (control) soybean meal. The processed soybean meal was added to formulated rodent diets at 20% (w/w) and fed to rats for 90 days. Some rats from the control group were separately administered mitomycin C for 40 days and served as positive controls in the sperm abnormality test. Body weights and behavior were monitored daily, serum enzymes and histologic and EM appearance of the testis, and sperm morphology were also examined. After 90 days of feeding, no adverse effects were observed in rats fed glyphosate-tolerant soybeans.
抗草甘膦大豆代表了全世界种植和用于饲养动物的大豆的很大一部分。尽管它们已经广泛使用了多年，但由于大豆是经过基因改造的，一些人对其安全性提出了质疑。赋予大豆耐受草甘膦表面施用的 CP4 EPSPS 基因被引入到大豆中。在大豆田中使用草甘膦可以降低杂草压力并提高大豆产量。为了评估它们对大鼠生殖系统的安全性，雄性 Sprague Dawley 大鼠分别喂食抗草甘膦（GM）大豆（40-3-2）或近等基因、非 GM（A5403）（对照）大豆粉。加工后的大豆粉以 20%（w/w）的比例添加到配方啮齿动物饮食中，并喂食大鼠 90 天。对照组中的一些大鼠分别接受丝裂霉素 C 治疗 40 天，并作为精子异常测试的阳性对照。每天监测体重和行为、血清酶和睾丸的组织学和 EM 外观以及精子形态。喂食抗草甘膦大豆 90 天后，未观察到大鼠出现不良反应。
