Center for Research, Diagnostics, and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taichung, Taiwan.
Center for Research, Diagnostics, and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taichung, Taiwan
Antimicrob Agents Chemother. 2019 Sep 23;63(10). doi: 10.1128/AAC.01122-19. Print 2019 Oct.
serovar Goldcoast infection was rare in Taiwan; it was not detected in routine surveillance from 2004 to 2013. This serovar was first identified in 2014, but the frequency of infection remained low until 2017. From 2014 to 2016, all but one isolate was pan-susceptible. Goldcoast infections abruptly increased in 2018, and all isolates were multidrug-resistant (MDR). All MDR isolates harbored an IncHI2 plasmid, and the majority carried 14 antimicrobial resistance genes, , , , , , , (F), , , , , , (A), and Goldcoast strains recovered in Taiwan and 96 of 99 strains from Germany, the Netherlands, the United Kingdom, and the United States belonged to sequence type 358 (ST358). Whole-genome single-nucleotide polymorphism and core genome multilocus sequence type analyses revealed that all strains of the ST358 clone shared a high degree of genetic relatedness. The present study highlighted that a dramatic increase in Goldcoast infections followed the emergence of MDR strains and indicated that a genetically closely related Goldcoast ST358 clone may have widespread significance internationally.
金海岸血清型感染在台湾很少见；在 2004 年至 2013 年的常规监测中未检测到。该血清型于 2014 年首次被发现，但感染频率一直很低，直到 2017 年。2014 年至 2016 年，除一个分离株外，所有分离株均对多种药物敏感。2018 年金海岸感染突然增加，所有分离株均为多药耐药（MDR）。所有 MDR 分离株均携带 IncHI2 质粒，大多数携带 14 种抗生素耐药基因，blaCTX-M-15，blaTEM-1，blaSHV-12，qnrS1，qnrB4，aac(6′)-Ib-cr，aadA1，strA，strB，tet(A)，tet(B)，tet(G)，mph(A)，和 catA1。从台湾和德国、荷兰、英国和美国回收的 96 株 99 株金海岸菌株属于序列型 358（ST358）。全基因组单核苷酸多态性和核心基因组多位点序列型分析表明，ST358 克隆的所有菌株具有高度的遗传相关性。本研究强调，MDR 菌株的出现导致金海岸感染急剧增加，并表明具有密切遗传关系的金海岸 ST358 克隆可能在国际上具有广泛的意义。
