美国女性中 gluten 摄入量与银屑病、银屑病关节炎和特应性皮炎的风险。
Gluten intake and risk of psoriasis, psoriatic arthritis, and atopic dermatitis among United States women.
机构信息
Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada; Women's College Research Institute and Division of Dermatology, Department of Medicine, Women's College Hospital, Toronto, Canada; Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
出版信息
J Am Acad Dermatol. 2020 Mar;82(3):661-665. doi: 10.1016/j.jaad.2019.08.007. Epub 2019 Aug 9.
BACKGROUND
Associations between gluten intake and psoriasis, psoriatic arthritis, and atopic dermatitis are poorly understood.
OBJECTIVE
To determine whether increased gluten intake is associated with incident psoriasis, psoriatic arthritis, and atopic dermatitis.
METHODS
Cohort studies among women in Nurses' Health Study II. Food frequency questionnaires were used to calculate gluten content of participants' diet every 4 years (1991-2015 for psoriatic disease, 1995-2013 for atopic dermatitis). Disease outcomes were assessed by self-report and subsequently validated. Multivariable-adjusted Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals for the association between gluten intake (quintiles) and psoriasis, psoriatic arthritis, and atopic dermatitis.
RESULTS
We included 85,185 participants in the psoriasis analysis, 85,324 in the psoriatic arthritis analysis, and 63,443 in the atopic dermatitis analysis. Increased gluten intake was not associated with any of the outcomes (all P for trend >.05). Comparing highest and lowest gluten intake quintiles, the multivariable hazard ratios (95% confidence intervals) were 1.15 (0.98-1.36) for psoriasis, 1.12 (0.78-1.62) for psoriatic arthritis, and 0.91 (0.66-1.25) for atopic dermatitis.
LIMITATIONS
No assessment of a strictly gluten-free diet.
CONCLUSIONS
Our findings do not support the amount of dietary gluten intake as a risk factor for psoriasis, psoriatic arthritis, or atopic dermatitis in adult women.
背景
目前对于麸质摄入与银屑病、银屑病关节炎和特应性皮炎之间的关联仍知之甚少。
目的
旨在确定增加的麸质摄入是否与新发银屑病、银屑病关节炎和特应性皮炎相关。
方法
对护士健康研究 II 中的女性进行队列研究。使用食物频率问卷每 4 年（银屑病发病相关为 1991-2015 年，特应性皮炎发病相关为 1995-2013 年）计算参与者饮食中的麸质含量。通过自我报告评估疾病结局，并随后进行验证。多变量调整的 Cox 比例风险模型用于计算麸质摄入量（五分位数）与银屑病、银屑病关节炎和特应性皮炎之间的关联的风险比和 95%置信区间。
结果
我们纳入了 85185 例银屑病分析、85324 例银屑病关节炎分析和 63443 例特应性皮炎分析。增加的麸质摄入与所有结局均无关（所有趋势 P 值均>.05）。与最低和最高麸质摄入五分位数相比，多变量风险比（95%置信区间）分别为 1.15（0.98-1.36）、1.12（0.78-1.62）和 0.91（0.66-1.25）。
局限性
未评估严格的无麸质饮食。
结论
我们的研究结果不支持膳食中麸质摄入量与成年女性银屑病、银屑病关节炎或特应性皮炎的发生风险有关。
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