Department of Dermatology and Venereology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Dermatology and Venereology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
PLoS One. 2021 Jan 11;16(1):e0243348. doi: 10.1371/journal.pone.0243348. eCollection 2021.
Psoriasis is a chronic immune-mediated disease and psoriatic arthritis is a common coexisting condition. Cardiorespiratory fitness is the overall capacity to perform exertion exercise. Low levels of cardiorespiratory fitness are associated with negative health outcomes. Individuals with psoriasis have lower cardiorespiratory fitness compared with individuals without psoriasis. There are no previous studies exploring the association between cardiorespiratory fitness and new-onset psoriasis and psoriatic arthritis.
With the objective to investigate whether low cardiorespiratory fitness in late adolescence increases the risk for onset of psoriasis and psoriatic arthritis, a cohort of Swedish men in compulsory military service between 1968 and 2005 was created using data from the Swedish Military Service Conscription Register. Cardiorespiratory fitness, estimated by maximum capacity cycle ergometer testing at conscription, was divided into three groups: high, medium, and low. Diagnoses were obtained using the Swedish National Patient Register and cohort members were followed from conscription until an event, new-onset psoriasis or psoriatic arthritis, occurred, or at the latest until 31 December 2016. Cox regression models adjusted for confounders at conscription were used to obtain hazard ratios with 95% confidence intervals for incident psoriasis and psoriatic arthritis.
During the follow-up period (median follow-up time 31 years, range 0-48 years), 20,679 cases of incident psoriasis and 6,133 cases of incident psoriatic arthritis were found among 1,228,562 men (mean age at baseline 18.3 years). There was a significant association between low cardiorespiratory fitness and incident psoriasis and psoriatic arthritis (hazard ratio 1.35 (95% confidence interval 1.26-1.44) and 1.44 (95% confidence interval 1.28-1.63), respectively).
These novel findings suggest that low cardiorespiratory fitness at an early age is associated with increased risk of incident psoriasis and psoriatic arthritis among men, and highlight the importance of assessing cardiorespiratory fitness early in life.
银屑病是一种慢性免疫介导性疾病，而银屑病关节炎是一种常见的并存疾病。心肺适能是指进行体力活动的整体能力。心肺适能水平低与不良健康结果有关。与没有银屑病的个体相比，银屑病患者的心肺适能较低。以前没有研究探讨心肺适能与新发银屑病和银屑病关节炎之间的关系。
为了研究青春期晚期心肺适能低下是否会增加银屑病和银屑病关节炎发病的风险，我们利用瑞典兵役登记处的数据，创建了一个 1968 年至 2005 年期间服兵役的瑞典男性队列。心肺适能通过征兵时最大容量测功仪测试来评估，分为高、中、低三组。通过瑞典国家患者登记处获得诊断，队列成员从入伍开始随访，直到发生新的银屑病或银屑病关节炎，或截至 2016 年 12 月 31 日。使用入伍时的混杂因素调整的 Cox 回归模型获得新发银屑病和银屑病关节炎的风险比及其 95%置信区间。
在随访期间（中位随访时间为 31 年，范围为 0-48 年），在 1228562 名男性中发现了 20679 例新发银屑病和 6133 例新发银屑病关节炎（基线时的平均年龄为 18.3 岁）。低心肺适能与新发银屑病和银屑病关节炎显著相关（风险比分别为 1.35（95%置信区间 1.26-1.44）和 1.44（95%置信区间 1.28-1.63））。
这些新发现表明，年轻时心肺适能低下与男性新发银屑病和银屑病关节炎的风险增加相关，强调了在生命早期评估心肺适能的重要性。
