Fan Hsin-Hsin, Weng Wei-Lun, Lee Chi-Young, Liao Chien-Neng
Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 30013 Taiwan, ROC.
ACS Omega. 2019 Jul 16;4(7):12222-12229. doi: 10.1021/acsomega.9b01730. eCollection 2019 Jul 31.
The glucose level is an important biological indicator for diabetes diagnosis. In contrast with costly and unstable enzymatic glucose sensing, oxide-based glucose sensors own the advantages of low fabrication cost, outstanding catalytic ability, and high chemical stability. Here, we fabricate a self-supporting spiky Cu O/Cu nanowire array structure by electrochemical cycling treatment. The spiky Cu O/Cu nanowire is identified to be a Cu core passivated by a conformal CuO layer with extruded CuO petals, which provides abundant active sites for electrocatalytic reaction in glucose detection. An interruptive potential sweeping experiment is presented to elucidate the growth mechanism of the spiky Cu O/Cu nanostructure during the potential cycling treatment. The spiky Cu O/Cu nanowire array electrode exhibits a sensitivity of 1210 ± 124 μA·mM·cm, a wide linear detection range of 0.01-7 mM, and a short response time (<1 s) for amperometric glucose sensing. The study demonstrates a route to modulate oxide phase, crystal morphology, and electrocatalytic properties of metal/oxide core-shell nanostructures.
血糖水平是糖尿病诊断的重要生物学指标。与成本高昂且不稳定的酶促葡萄糖传感相比，基于氧化物的葡萄糖传感器具有制造成本低、催化能力出色和化学稳定性高的优点。在此，我们通过电化学循环处理制备了一种自支撑的尖刺状CuO/Cu纳米线阵列结构。尖刺状CuO/Cu纳米线被确定为具有由带有挤压CuO花瓣的共形CuO层钝化的Cu核，这为葡萄糖检测中的电催化反应提供了丰富的活性位点。进行了中断电位扫描实验以阐明尖刺状CuO/Cu纳米结构在电位循环处理过程中的生长机制。尖刺状CuO/Cu纳米线阵列电极在安培型葡萄糖传感中表现出1210±124μA·mM·cm的灵敏度、0.01 - 7 mM的宽线性检测范围和短响应时间（<1 s）。该研究展示了一种调节金属/氧化物核壳纳米结构的氧化物相、晶体形态和电催化性能的途径。
