Thayer School of Engineering, Dartmouth College Hanover, Hanover, NH, 03755, USA.
Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 03756, USA.
Med Phys. 2019 Nov;46(11):5227-5237. doi: 10.1002/mp.13797. Epub 2019 Oct 4.
We demonstrate the feasibility of optical imaging as a quality assurance tool for static small beamlets, and pretreatment verification tool for radiosurgery and volumetric-modulated arc therapy (VMAT) plans.
Small static beams and clinical VMAT plans were simulated in a treatment planning system (TPS) and delivered to a cylindrical tank filled with water-based liquid scintillator. Emission was imaged using a blue-sensitive, intensified CMOS camera time-gated to the linac pulses. For static beams, percentage depth and cross beam profiles of projected intensity distribution were compared to TPS data. Two-dimensional (2D) gamma analysis was performed on all clinical plans, and the technique was tested for sensitivity against common errors (multileaf collimator position, gantry angle) by inducing deliberate errors in the VMAT plans control points. The technique's detection limits for spatial resolution and the smallest number of control points that could be imaged reliably were also tested. The sensitivity to common delivery errors was also compared against a commercial 2.5D diode array dosimeter.
A spatial resolution of 1 mm was achieved with our imaging setup. The optical projected percentage depth intensity profiles agreed to within 2% relative to the TPS data for small static square beams (5, 10, and 50 mm ). For projected cross beam profiles, a gamma pass rate >99% was achieved for a 3%/1 mm criteria. All clinical plans passed the 3%/3 mm criteria with >95% passing rate. A static 5 mm beam with 20 Monitor Units could be measured with an average percent difference of 5.5 ± 3% relative to the TPS. The technique was sensitive to multileaf collimator errors down to 1 mm and gantry angle errors of 1°.
Optical imaging provides ample spatial resolution for imaging small beams. The ability to faithfully image down to 20 MU of 5 mm, 6 MV beamlets prove the ability to perform quality assurance for each control point within dynamic plans. The technique is sensitive to small offset errors in gantry angles and multileaf collimator (MLC) leaf positions, and at certain scenario, it exhibits higher sensitivity than a commercial 2.5D diode array.
我们展示了光学成像是一种用于静态小射束的质量保证工具,以及一种用于放射外科和容积调强弧形治疗(VMAT)计划的预处理验证工具的可行性。
在治疗计划系统(TPS)中模拟小静态射束和临床 VMAT 计划,并将其输送到充满水基液体闪烁体的圆柱形水箱中。使用对 linac 脉冲进行时间门控的蓝色敏感、增强型 CMOS 相机对发射进行成像。对于静态射束,将投影强度分布的百分深度和横截面射束轮廓与 TPS 数据进行比较。对所有临床计划进行二维(2D)伽马分析,并通过在 VMAT 计划控制点中引入故意错误来测试该技术对常见错误(多叶准直器位置、机架角度)的敏感性。还测试了该技术对空间分辨率的检测限和可以可靠成像的最小控制点数量。还将该技术对常见传输误差的敏感性与商业 2.5D 二极管阵列剂量计进行了比较。
我们的成像设置实现了 1 毫米的空间分辨率。对于小的静态方形射束(5、10 和 50 毫米),光学投影的百分深度强度轮廓与 TPS 数据的相对差异在 2%以内。对于投影的横截面射束轮廓,在 3%/1 毫米标准下,伽马通过率>99%。所有临床计划均通过 3%/3 毫米标准,通过率>95%。可以用 TPS 测量具有 20 个监视器单位的 5 毫米静态射束,平均百分比差异为 5.5±3%。该技术对多叶准直器误差敏感,低至 1 毫米,对机架角度误差敏感,低至 1°。
光学成像是一种用于成像小射束的方法,它具有足够的空间分辨率。能够真实地对 6MV 的 5 毫米、20 个 MU 的小射束进行成像,证明了对动态计划中每个控制点进行质量保证的能力。该技术对机架角度和多叶准直器(MLC)叶片位置的小偏移误差敏感,在某些情况下,它比商业 2.5D 二极管阵列具有更高的灵敏度。