El-Shamy Karima A, Koriem Khaled M M, Fadl Nevein N, El-Azma Marwa H A, Arbid Mahmoud S S, Morsy Fatma A, El-Zayat Salwa R, Hosny Eman N, Youness Eman R
Department of Medical Physiology, National Research Centre, 33 El-Behouth Street, Dokki, Giza, Cairo 12622, Egypt.
Department of Pharmacology, Medical Research Division, National Research Centre, Dokki, Cairo, Egypt.
J Complement Integr Med. 2019 Sep 6;17(2):/j/jcim.2020.17.issue-2/jcim-2019-0028/jcim-2019-0028.xml. doi: 10.1515/jcim-2019-0028.
Background Depression is a psychiatric disease condition and the chronic mild stress (CMS) model is a well-known and valuable animal model of depression. Geranium oil and anise oil were chosen for such a study. The aim of this research was to establish the geranium oil and anise oil effect to ameliorate CMS-related symptoms. Methods This research included 80 male albino rats each group of 10 rats and the animals were divided into two major groups: normal and CMS. The normal group was subdivided into four (control, geranium oil, anise oil and venlafaxine drug) subgroups treated orally with saline, geranium oil, anise oil and venlafaxine drug, respectively, for 4 weeks. The CMS group was subdivided into four (CMS without any treatment, CMS + geranium oil, CMS + anise oil and CMS + venlafaxine drug) subgroups treated orally with geranium oil, anise oil and venlafaxine drug, respectively, for 4 weeks. Results The sucrose consumption in sucrose preference test, the distance traveled test and center square entries test were decreased, while center square duration test, immobility time in tail suspension test and floating time in forced swimming test were increased in CMS. The superoxide dismutase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and catalase levels decreased but malondialdehyde and nitric oxide levels increased in brain cerebral cortex and hippocampus areas in CMS. The oral intake of geranium oil and anise oil pushes all these parameters to approach the control levels. These results were supported by histopathological investigations of both brain cerebral cortex and hippocampus tissues. Conclusions Geranium oil and anise oil ameliorate CMS-related symptoms and this effect were related to the antioxidant effects of oils.
抑郁症是一种精神疾病，慢性轻度应激（CMS）模型是一种著名且有价值的抑郁症动物模型。本研究选用了天竺葵油和茴芹油。本研究的目的是确定天竺葵油和茴芹油改善CMS相关症状的效果。方法：本研究包括80只雄性白化大鼠，每组10只，动物被分为两大组：正常组和CMS组。正常组再细分为四个（对照、天竺葵油、茴芹油和文拉法辛药物）亚组，分别口服生理盐水、天竺葵油、茴芹油和文拉法辛药物，持续4周。CMS组再细分为四个（未治疗的CMS、CMS + 天竺葵油、CMS + 茴芹油和CMS + 文拉法辛药物）亚组，分别口服天竺葵油、茴芹油和文拉法辛药物，持续4周。结果：在CMS组中，蔗糖偏好试验中的蔗糖消耗量、旷场试验中的行进距离试验和中央方格进入试验均降低，而中央方格停留时间试验、悬尾试验中的不动时间和强迫游泳试验中的漂浮时间均增加。CMS组大脑皮层和海马区的超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽 - S - 转移酶、谷胱甘肽还原酶和过氧化氢酶水平降低，但丙二醛和一氧化氮水平升高。口服天竺葵油和茴芹油使所有这些参数接近对照水平。大脑皮层和海马组织的组织病理学研究支持了这些结果。结论：天竺葵油和茴芹油可改善CMS相关症状，且这种作用与油的抗氧化作用有关。
