肠道微生物群与神经疾病。
Gut Microbiota in Neurological Disorders.
机构信息
Department of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, Warsaw, Poland.
Department of Adult Infectious Diseases, Medical University of Warsaw, Warsaw, Poland.
出版信息
Arch Immunol Ther Exp (Warsz). 2019 Dec;67(6):375-383. doi: 10.1007/s00005-019-00561-6. Epub 2019 Oct 1.
Abstract
The incidence of neurological disorders such as multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD) is increasing throughout the world, but their pathogenesis remains unclear and successful treatment remains elusive. Bidirectional communications between the central nervous system and gut microbiota may play some role in the pathogenesis of the above disorders. Up to a thousand bacterial species reside in human intestine; they colonize the gut shortly after birth and remain for life. Numerous studies point to the role of microbiota composition in the development, course and treatment of MS, AD and PD.
摘要
世界各地神经紊乱疾病（如多发性硬化症、老年痴呆症和帕金森病）的发病率正在上升，但它们的发病机制仍不清楚，成功的治疗方法也难以捉摸。中枢神经系统与肠道微生物群之间的双向通讯可能在这些疾病的发病机制中发挥了一些作用。多达一千种细菌种类存在于人类肠道中；它们在出生后不久就定植于肠道，并终生存在。大量研究指出了微生物群组成在多发性硬化症、老年痴呆症和帕金森病的发展、病程和治疗中的作用。
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