Alimi D, Abidi A, Sebai E, Rekik M, Maizels R M, Dhibi M, Akkari H
Laboratoire de Parasitologie, Université de la Manouba, École Nationale de Médecine Vétérinaire de Sidi thabet, 2020, Sidi thabet, Tunisia.
Faculté des sciences de Bizerte, Université de Carthage, 7021, Zarzouna, Carthage, Tunisia.
Helminthologia. 2018 Jun 1;55(2):112-118. doi: 10.2478/helm-2018-0001. eCollection 2018 Jun.
Following our previous findings on the anthelmintic effect of camel milk on , the current study aimed at investigating its effect. Investigations were carried out using mice infected with which is a parasite commonly used to test the efficacy of anthelmintics. Thirty six Swiss white mice of both sexes aged 5 - 6 weeks old, and weighing between 20 and 25 g were orally infected with 0.5 ml dose of 100, 1-week-old infective larvae (L). After the pre-patent period, infected animals were randomly divided into 6 groups of 6 animals each. The nematicidal efficacy of camel milk was monitored through faecal egg count reduction (FECR) and total worm count reduction (TWCR). Four doses (8.25; 16.5; 33.0; 66.0 ml/kg body weight (bw)) for fresh camel milk and 22 mg/kg bw for albendazole were studied using a bioassay. Albendazole and 4 % dimethylsulfoxide were included in the protocol as reference drug and placebo, respectively. For all tested doses except 8.25 ml/kg bw, camel milk was effective against reducing both faecal egg count and worm count (p < 0.05). The dose 66 ml/kg bw showed the highest nematicidal activity causing a 76.75 % FECR and a 69.62 % TWCR 7 day after initiating the treatment. These results support the possible use of camel milk in the control of gastro-intestinal helminthiasis.
基于我们之前关于骆驼奶对[寄生虫名称未给出]驱虫效果的研究结果，本研究旨在调查其[具体效果未明确]效果。研究使用感染了[寄生虫名称未给出]的小鼠进行，[寄生虫名称未给出]是一种常用于测试驱虫药疗效的寄生虫。选取36只5 - 6周龄、体重在20至25克之间的瑞士小白鼠，雌雄皆有，每只经口感染0.5毫升剂量的100条1周龄的[寄生虫名称未给出]感染性幼虫（L）。在潜隐期过后，将感染的动物随机分为6组，每组6只。通过粪便虫卵计数减少率（FECR）和虫体总数减少率（TWCR）来监测骆驼奶的杀线虫效果。使用生物测定法研究了新鲜骆驼奶的四个剂量（8.25；16.5；33.0；66.0毫升/千克体重（bw））以及阿苯达唑22毫克/千克体重的效果。方案中分别将阿苯达唑和4%二甲亚砜作为参比药物和安慰剂。除8.25毫升/千克体重外，所有测试剂量的骆驼奶对[寄生虫名称未给出]均有效，可降低粪便虫卵计数和虫体计数（p < 0.05）。在开始治疗7天后，66毫升/千克体重的剂量显示出最高的杀线虫活性，导致粪便虫卵计数减少率为76.75%，虫体总数减少率为69.62%。这些结果支持骆驼奶在控制胃肠道蠕虫病方面的潜在应用。
