Zhang Yanmei, Zhang Xin, Song Jie, Jin Liming, Wang Xiaotong, Quan Chunshan
College of Life Science, Dalian Minzu University, Economical and Technological Development Zone, Dalian 116600, China.
Key Laboratory of Biotechnology and Bioresources Utilization, Dalian Minzu University, Ministry of Education, Dalian 116600, China.
Nanomaterials (Basel). 2019 Nov 7;9(11):1579. doi: 10.3390/nano9111579.
Development of antimicrobial nanomaterials is one of the most attractive strategies for eliminating the major threat of pathogenic bacteria to public health. In this work, we developed a simple impregnation-reduction method for the synthesis of Ag-doped hierarchical ZIF-8 (Ag/H-ZIF-8) nanocomposite. The nanocomposite was characterized by several techniques and its antibacterial activity was investigated. The Ag nanoparticles are uniformly dispersed in the porous ZIF-8 with narrow size distribution. Consequently, the resulting Ag/H-ZIF-8 nanocomposite showed significantly enhanced antibacterial activities compared to the single ZIF-8 or Ag nanoparticles. Furthermore, the composite is biocompatible, because no obvious toxicity was observed on Hepatic epithelial cells. This study offers a new approach for the design of hybrid antimicrobial nanomaterials that have great potentials in practical disinfections.
开发抗菌纳米材料是消除致病细菌对公众健康构成的主要威胁的最具吸引力的策略之一。在这项工作中，我们开发了一种简单的浸渍还原法来合成银掺杂的分级ZIF-8（Ag/H-ZIF-8）纳米复合材料。通过多种技术对该纳米复合材料进行了表征，并研究了其抗菌活性。银纳米颗粒均匀分散在孔径分布窄的多孔ZIF-8中。因此，与单一的ZIF-8或银纳米颗粒相比，所得的Ag/H-ZIF-8纳米复合材料显示出显著增强的抗菌活性。此外，该复合材料具有生物相容性，因为在肝上皮细胞上未观察到明显的毒性。本研究为设计在实际消毒中具有巨大潜力的混合抗菌纳米材料提供了一种新方法。
