Banerjee Ritu, Starke Jeffrey R
Division of Pediatric Infectious Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States.
Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
J Clin Tuberc Other Mycobact Dis. 2016 Apr 1;3:28-34. doi: 10.1016/j.jctube.2016.03.004. eCollection 2016 May.
There are striking similarities between the dual pandemics of multidrug-resistant tuberculosis (MDR TB) and multidrug-resistant Gram negative bacilli (MDR GNB) despite fundamental differences in the pathogenesis and epidemiology of these pathogens. In this perspective, we highlight several strategies that have been used by the global TB community to address the MDR TB problem, including approaches to: encourage appropriate use of anti-TB medications, enhance appropriate utilization of molecular diagnostic testing, facilitate development of new antimicrobial agents, and strengthen surveillance systems and infection control practices. Understanding the successes and challenges of these strategies for MDR TB control will be instructive for efforts to curb emergence and spread of MDR GNB.
耐多药结核病（MDR TB）和耐多药革兰氏阴性杆菌（MDR GNB）这两种大流行疾病之间存在显著相似之处，尽管这些病原体在发病机制和流行病学方面存在根本差异。从这个角度来看，我们强调了全球结核病界为解决耐多药结核病问题所采用的几种策略，包括以下方法：鼓励合理使用抗结核药物、加强分子诊断检测的合理利用、促进新型抗菌药物的研发，以及加强监测系统和感染控制措施。了解这些耐多药结核病控制策略的成功经验和挑战，将为遏制耐多药革兰氏阴性杆菌的出现和传播提供指导。
