基于机器学习的智能手机眼压计的研发与验证。
Development and validation of a machine learning, smartphone-based tonometer.
机构信息
Ophthalmology, University of Washington, Seattle, Washington, USA.
University of Washington, Seattle, Washington, USA.
出版信息
Br J Ophthalmol. 2020 Oct;104(10):1394-1398. doi: 10.1136/bjophthalmol-2019-315446. Epub 2019 Dec 23.
BACKGROUND/AIMS: To compare intraocular pressure (IOP) measurements using a prototype smartphone tonometer with other tonometers used in clinical practice.
METHODS
Patients from an academic glaucoma practice were recruited. The smartphone tonometer uses fixed force applanation and in conjunction with a machine-learning computer algorithm is able to calculate the IOP. IOP was also measured using Goldmann applanation tonometry (GAT) in all subjects. A subset of patients were also measured using ICare, pneumotonometry (upright and supine positions) and Tono-Pen (upright and supine positions) and the results were compared.
RESULTS
92 eyes of 81 subjects were successfully measured. The mean difference (in mm Hg) for IOP measurements of the smartphone tonometer versus other devices was +0.24 mm Hg for GAT, -1.39 mm Hg for ICare, -3.71 mm Hg for pneumotonometry and -1.30 mm Hg for Tono-Pen. The 95% limits of agreement for the smartphone tonometer versus other devices was -4.35 to 4.83 mm Hg for GAT, -6.48 to 3.70 mm Hg for ICare, -7.66 to -0.15 mm Hg for pneumotonometry and -5.72 to 3.12 mm Hg for Tono-Pen. Overall, the smartphone tonometer results correlated best with GAT (R=0.67, p<0.001). Of the 92 videos, 90 (97.8%) were within ±5 mm Hg of GAT and 58 (63.0%) were within ±2 mm Hg of GAT.
CONCLUSIONS
Preliminary IOP measurements using a prototype smartphone-based tonometer was grossly equivalent to the reference standard.
背景/目的：比较原型智能手机眼压计与临床实践中使用的其他眼压计测量的眼压（IOP）。
方法
从学术青光眼实践中招募患者。智能手机眼压计使用固定力压平，并结合机器学习计算机算法，能够计算 IOP。所有受试者均使用 Goldmann 压平眼压计（GAT）测量 IOP。部分患者还使用 ICare、气动眼压计（仰卧和仰卧位）和 Tono-Pen（仰卧和仰卧位）进行测量，并比较结果。
结果
成功测量了 81 名受试者的 92 只眼。智能手机眼压计与其他设备的 IOP 测量值之间的平均差值（mmHg）分别为 GAT 为+0.24mmHg、ICare 为-1.39mmHg、气动眼压计为-3.71mmHg 和 Tono-Pen 为-1.30mmHg。智能手机眼压计与其他设备的 95%一致性界限分别为 GAT 为-4.35 至 4.83mmHg、ICare 为-6.48 至 3.70mmHg、气动眼压计为-7.66 至-0.15mmHg 和 Tono-Pen 为-5.72 至 3.12mmHg。总体而言，智能手机眼压计与 GAT 的相关性最好（R=0.67，p<0.001）。在 92 个视频中，90 个（97.8%）在 GAT 的±5mmHg 以内，58 个（63.0%）在 GAT 的±2mmHg 以内。
结论
使用原型基于智能手机的眼压计进行初步 IOP 测量与参考标准大致相当。
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