小鼠脾细胞的有丝分裂原刺激：与沙门氏菌感染易感性的关系。
Mitogenic stimulation of murine spleen cells: relation to susceptibility to Salmonella infection.
作者信息
von Jeney N, Günther E, Jann K
出版信息
Infect Immun. 1977 Jan;15(1):26-33. doi: 10.1128/iai.15.1.26-33.1977.
Abstract
The screening of several inbred strains of mice suggested that the capacity of their spleen cells to respond to the mitogenic effect of lipopolysaccharide (LPS) of gram-negative bacteria was correlated with their resistance to intraperitoneal infection with Salmonella typhimurium. An infection of LPS into mice caused changes in the in vitro responsiveness of their spleen cells to the mitogenic effects of LPS and phytohemagglutinin. Pretreatment of mice with whole ultraviolet (UV)-killed bacteria led to a marked rise in the in vitro response of the spleen cells to UV-killed bacteria, but not to LPS or or phytohemagglutinin. This enhanced response to UV-killed bacteria was not specific for the O antigens of the bacteria.
摘要
对几种近交系小鼠的筛选表明，其脾细胞对革兰氏阴性菌脂多糖（LPS）促有丝分裂作用的反应能力与其对鼠伤寒沙门氏菌腹腔感染的抵抗力相关。给小鼠注射LPS会导致其脾细胞在体外对LPS和植物血凝素促有丝分裂作用的反应性发生变化。用经紫外线（UV）完全灭活的细菌对小鼠进行预处理，会导致脾细胞对经UV灭活细菌的体外反应显著增强，但对LPS或植物血凝素则无此作用。这种对经UV灭活细菌的增强反应并非针对细菌的O抗原。
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