Yoon Ji-Seon, Kim Suhee, Kang Jin-Hee, Park Jinho, Yu DoHyeon
College of Veterinary Medicine, Chonbuk National University, Iksan 54596, Korea (Yoon, Kang, Park); Gyeongsang National University Hospital, Jinju 52727, Korea (Kim); College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Korea (Yu).
Can J Vet Res. 2020 Jan;84(1):74-78.
The quantification of serum proteins is a useful tool for diagnosing and monitoring various diseases that involve changes in the concentrations of these proteins. As canine acute pancreatitis (AP) accompanies the systemic inflammatory response syndrome, serum proteins such as C-reactive protein (CRP) have been used as inflammatory markers for dogs with AP. The goal of this study was to investigate the overall profiles of serum proteins by serum protein electrophoresis (SPE) and to determine the concentration of acute phase proteins (APPs) in dogs with AP in order to better understand serum protein profiles as diagnostic markers in these dogs. Decreased levels of albumin and increased levels of alpha-2 globulin were observed in dogs with AP by SPE. Among APPs, elevated concentrations of CRP, serum amyloid A (SAA), and haptoglobin were detected. The concentration of SAA was positively correlated with that of CRP, which suggests that SAA could be a sensitive marker of inflammation in dogs with AP, similar to CRP.
血清蛋白的定量分析是诊断和监测各种涉及这些蛋白质浓度变化疾病的有用工具。由于犬急性胰腺炎（AP）伴有全身炎症反应综合征，血清蛋白如C反应蛋白（CRP）已被用作患有AP的犬的炎症标志物。本研究的目的是通过血清蛋白电泳（SPE）研究血清蛋白的整体概况，并确定患有AP的犬中急性期蛋白（APPs）的浓度，以便更好地了解血清蛋白概况作为这些犬的诊断标志物。通过SPE观察到患有AP的犬白蛋白水平降低和α-2球蛋白水平升高。在APPs中，检测到CRP、血清淀粉样蛋白A（SAA）和触珠蛋白浓度升高。SAA的浓度与CRP的浓度呈正相关，这表明SAA可能是患有AP的犬炎症的敏感标志物，类似于CRP。
