海洋来源真菌 sp. KFD33 中具有群体感应抑制活性的交替毒素。
Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus sp. KFD33.
机构信息
Hainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, Lianyungang 222005, China.
出版信息
Mar Drugs. 2020 Jan 19;18(1):67. doi: 10.3390/md18010067.
Five new perylenequinone derivatives, altertoxins VIII-XII (-), as well as one known compound cladosporol I (), were isolated from the fermentation broth of the marine-derived fungus sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds - exhibited quorum sensing inhibitory activities against CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively.
从中国海口湾血蛤中分离到一株海洋来源真菌 sp. KFD33 的发酵液中，分离得到五个新的苝醌衍生物（ altertoxins VIII-XII (-)）和一个已知化合物 cladosporol I (())。基于光谱方法和 ECD 光谱分析以及量子 ECD 计算确定了它们的结构。化合物 - 对 CV026 表现出群体感应抑制活性，MIC 值分别为 30、30、20、30、20 和 30 μg/孔。
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