Faculty of Information Technology, Beijing University of Technology, Beijing, 100124, China.
State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Sci Rep. 2020 Jan 28;10(1):1365. doi: 10.1038/s41598-020-58403-x.
Non-enzymatic electrodes based on noble metals have excellent selectivity and high sensitivity in glucose detection but no such shortcomings as easy to be affected by pH, temperature, and toxic chemicals. Herein, spherical gold-nickel nanoparticles with a core-shell construction (Au@Ni) are prepared by oleylamine reduction of their metal precursors. At an appropriate Au/Ni ratio, the core-shell Au@Ni nanoparticles as a sensor for glucose detection combine the high electrocatalytic activity, good selectivity and biological compatibility of Au with the remarkable tolerance of Ni for chlorine ions (Cl) and poisoning intermediates in catalytic oxidation of glucose. This electrode exhibits a low operating voltage of 0.10 V vs. SCE for glucose oxidation, leading to higher selectivity compared with other Au- and Ni-based sensors. The linear range for the glucose detection is from 0.5 mmol L to 10 mmol L with a rapid response time of ca. 3 s, good stability, sensitivity estimated to be 23.17 μA cm mM, and a detection limit of 0.0157 mM. The sensor displays high anti-toxicity, and is not easily poisoned by the adsorption of Cl in solution.
基于贵金属的非酶电极在葡萄糖检测中具有优异的选择性和高灵敏度，但不存在易受 pH 值、温度和有毒化学物质影响等缺点。在此，通过金属前体的油胺还原制备了具有核壳结构的球形金镍纳米粒子（Au@Ni）。在适当的 Au/Ni 比下，作为葡萄糖检测传感器的核壳 Au@Ni 纳米粒子结合了 Au 的高电催化活性、良好的选择性和生物相容性，以及 Ni 对氯离子（Cl）和葡萄糖催化氧化中毒中间体的显著耐受性。与其他基于 Au 和 Ni 的传感器相比，该电极的葡萄糖氧化的工作电压低至 0.10 V vs. SCE，从而具有更高的选择性。葡萄糖检测的线性范围为 0.5 mmol·L 至 10 mmol·L，响应时间快约 3 s，稳定性好，灵敏度估计为 23.17 μA·cm·mM，检测限为 0.0157 mM。该传感器具有高抗毒性，不易被溶液中 Cl 的吸附所毒害。
