Juntendo University Graduate School of Medicine, Department of Ophthalmology, Tokyo, Japan.
Juntendo University Faculty of Medicine, Department of Ophthalmology, Tokyo, Japan.
PLoS One. 2020 Feb 3;15(2):e0228567. doi: 10.1371/journal.pone.0228567. eCollection 2020.
The purpose of this study was to compare central corneal thickness, thinnest corneal thickness, and the thinnest point of the cornea between Pentacam and anterior segment optical coherence tomography (ASOCT) in patients with dry eye disease (DED). This cross-sectional study included 195 participants between November 2015-June 2017. DED was diagnosed using the Asia Dry Eye Society criteria and further divided into mild and severe DED based on kerato-conjunctival vital staining. Central corneal thickness, thinnest corneal thickness, and the thinnest point of the cornea measured by Pentacam and ASOCT were compared, and Pearson's correlation coefficients were estimated. The differences in central corneal thickness and the thinnest corneal thickness between Pentacam and ASOCT were analysed using Bland-Altman and multivariate regression analyses adjusted for age and sex. This study included 70 non-DED subjects and 52 patients with mild and 73 with severe DED. The Pentacam and ASOCT measurements of central corneal thickness and thinnest corneal thickness were strongly correlated, but the respective values were higher when measured with Pentacam. The Bland-Altman analysis revealed differences in central corneal thickness (non DED, 11.8; mild DED, 13.2; severe DED, 19.6) and in thinnest corneal thickness (non DED, 13.1; mild DED, 13.4; severe DED, 20.7). After adjusting for age and sex, the differences in central corneal thickness (β = 7.029 μm, 95%CI 2.528-11.530) and thinnest corneal thickness (β = 6.958 μm, 95%CI 0.037-13.879) were significantly increased in the severe-DED group. The distribution of the thinnest point of the cornea in the cornea's inferior temporal quadrant between Pentacam and ASOCT deviated in severe DED (Pentacam: 90.4% vs. ASOCT: 83.6%). Clinicians should consider that there were significant differences in corneal-morphology assessment between the measurements with Pentacam and ASOCT in severe DED.
本研究旨在比较 Pentacam 和眼前段光学相干断层扫描（ASOCT）在干眼症（DED）患者中测量的中央角膜厚度、最薄角膜厚度和角膜最薄点。这是一项横断面研究，纳入了 2015 年 11 月至 2017 年 6 月间的 195 名参与者。DED 的诊断采用亚洲干眼协会标准，并根据角结膜荧光素染色进一步分为轻度和重度 DED。比较了 Pentacam 和 ASOCT 测量的中央角膜厚度、最薄角膜厚度和角膜最薄点，并估计了 Pearson 相关系数。使用 Bland-Altman 分析和多元回归分析比较了 Pentacam 和 ASOCT 测量的中央角膜厚度和最薄角膜厚度之间的差异，并调整了年龄和性别因素。本研究包括 70 名非 DED 患者、52 名轻度 DED 患者和 73 名重度 DED 患者。Pentacam 和 ASOCT 测量的中央角膜厚度和最薄角膜厚度呈强相关，但 Pentacam 测量的结果值更高。Bland-Altman 分析显示，中央角膜厚度（非 DED：11.8μm；轻度 DED：13.2μm；重度 DED：19.6μm）和最薄角膜厚度（非 DED：13.1μm；轻度 DED：13.4μm；重度 DED：20.7μm）存在差异。调整年龄和性别后，重度 DED 组的中央角膜厚度（β=7.029μm，95%CI 2.528-11.530）和最薄角膜厚度（β=6.958μm，95%CI 0.037-13.879）的差异显著增加。Pentacam 和 ASOCT 测量的角膜最薄点在角膜下颞象限的分布在重度 DED 中存在差异（Pentacam：90.4% vs. ASOCT：83.6%）。临床医生应注意，在重度 DED 中，Pentacam 和 ASOCT 测量的角膜形态评估存在显著差异。
