荨麻疹和特应性皮炎患者的睡眠障碍：被低估的负担。
Sleep Disturbance in Patients with Urticaria and Atopic Dermatitis: An Underestimated Burden.
机构信息
Department of Dermatology, Johannes-Gutenberg Universtity, DE-55131 Mainz, Germany.
出版信息
Acta Derm Venereol. 2020 Mar 12;100(6):adv00073. doi: 10.2340/00015555-3416.
This study examined the relationship between insomnia and the frequent itching skin diseases, atopic dermatitis and chronic urticaria. Patients with chronic inflammatory dermatological diseases with pruritus were evaluated for insomnia (Insomnia Severity Index; ISI) and impairment in dermatological quality of life (Dermatology Life Quality Index; DLQI). Disease activity was measured using validated scores. A total of 61 patients participated in the study. Patients with atopic dermatitis had a mean ISI score of 8.7 before flares and 16 when a flare occurred. The mean DLQI score in atopic dermatitis was 11.4. The mean ISI score in patients with chronic urticaria was 6.8 before flares and 14.9 when a flare occurred. In patients with chronic urticaria the mean DLQI score was 8.5. An increase in insomnia during a disease flare was demonstrated in both groups. Thus, sleep is a factor to consider during treatment of itching skin diseases. The results of this pilot study indicate that pruritus may not be the only reason for insomnia in patients with atopic dermatitis or chronic urticaria.
本研究探讨了失眠与常见瘙痒性皮肤疾病，特应性皮炎和慢性荨麻疹之间的关系。对患有瘙痒性慢性炎症性皮肤病的患者进行失眠（失眠严重程度指数；ISI）和皮肤病生活质量受损（皮肤病生活质量指数；DLQI）评估。使用经过验证的评分来衡量疾病活动。共有 61 名患者参与了这项研究。特应性皮炎患者在发作前的平均 ISI 评分为 8.7，发作时为 16。特应性皮炎的平均 DLQI 评分为 11.4。慢性荨麻疹患者在发作前的平均 ISI 评分为 6.8，发作时为 14.9。慢性荨麻疹患者的平均 DLQI 评分为 8.5。两组患者在疾病发作期间均显示失眠增加。因此，在治疗瘙痒性皮肤病时应考虑睡眠因素。这项初步研究的结果表明，瘙痒可能不是特应性皮炎或慢性荨麻疹患者失眠的唯一原因。
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