Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Viral Immunol. 2020 May;33(4):282-293. doi: 10.1089/vim.2019.0141. Epub 2020 Feb 5.
In mammals, adaptive immunity is mediated by a broadly diverse repertoire of naive B and T lymphocytes that recirculate between secondary lymphoid organs. Initial antigen exposure promotes lymphocyte clonal expansion and differentiation, including the formation of memory cells. Antigen-specific memory cells are maintained at higher frequencies than their naive counterparts and have different functional and homing abilities. Importantly, a subset of memory cells, known as tissue-resident memory cells, is maintained without recirculating in nonlymphoid tissues, often at barrier surfaces, where they can be reactivated by antigen and rapidly perform effector functions that help protect the tissue in which they reside. Although antigen-experienced B cells are abundant at many barrier surfaces, their characterization as tissue-resident memory B (BRM) cells is not well developed. In this study, we describe the characteristics of memory B cells in various locations and discuss their possible contributions to immunity and homeostasis as BRM cells.
在哺乳动物中，适应性免疫由广泛多样的幼稚 B 和 T 淋巴细胞介导，这些淋巴细胞在次级淋巴器官之间循环。初次抗原暴露促进淋巴细胞克隆扩增和分化，包括记忆细胞的形成。抗原特异性记忆细胞的频率高于其幼稚细胞，具有不同的功能和归巢能力。重要的是，记忆细胞的一个亚群，称为组织驻留记忆细胞，在非淋巴组织中不循环的情况下得以维持，通常在屏障表面，在那里它们可以被抗原重新激活，并迅速发挥效应功能，有助于保护它们所在的组织。尽管在许多屏障表面都存在大量抗原经验的 B 细胞，但它们作为组织驻留记忆 B（BRM）细胞的特征尚未得到很好的发展。在这项研究中，我们描述了各种位置记忆 B 细胞的特征，并讨论了它们作为 BRM 细胞对免疫和稳态的可能贡献。
