Cho So Yean, Kang Shin Jung, Jung Joohee, Jeong Byeong Ok, Jeong Choon Sik
13Herbal Medicine Evaluation Team, Korea Food & Drug Administration, Seoul, 122-704 Korea.
23College of Pharmacy, Duksung Women's University, Seoul, 132-714 Korea.
Toxicol Res. 2009 Sep;25(3):125-131. doi: 10.5487/TR.2009.25.3.125. Epub 2009 Sep 1.
Korea is representative of a country that consumes herbal medicines; most of the herbal medicines circulating in South Korea have been imported from developing countries in Southeast Asia, such as China and Indonesia. Recently, domestic hygiene and safety are issues that have come to the forefront, because herbal medicines currently in circulation could possibly contain contaminants or residues. Furthermore, the appearance or discovery of harmful new species due to environmental and industrial developments is becoming a social problem. Therefore, it may be necessary to consider and investigate these matters on a continual basis. Recently, mycotoxin contaminations in such foods as cereals, nuts, and powdered red pepper have been reported. They have become a problematic issue; the possibility of contamination in herbal medicines has also been considered. Nevertheless, recognition of and research into mycotoxin contamination in herbal medicines has been scarce because herbal medicine is used in only a few nations. In this research, we identified contamination by aflatoxin which is known to be the most potent mutagenic, carcinogenic, and teratoge-nic mycotoxin in Thujae Semen, a herbal medicine. We also found co-contaminations involving other mycotoxins, including ochratoxin A and zeraleanone.
韩国是草药消费大国的代表;韩国流通的大多数草药都是从中国和印度尼西亚等东南亚发展中国家进口的。最近,国内卫生和安全问题成为了首要问题,因为目前流通的草药可能含有污染物或残留物。此外,由于环境和工业发展导致有害新物种的出现或发现正成为一个社会问题。因此,可能有必要持续考虑和调查这些问题。最近,已有报道称谷物、坚果和辣椒粉等食品中存在霉菌毒素污染。它们已成为一个有问题的问题;草药中污染的可能性也已被考虑在内。然而,由于只有少数国家使用草药,对草药中霉菌毒素污染的认识和研究一直很少。在本研究中,我们鉴定出了在草药侧柏叶中已知最具致突变性、致癌性和致畸性的霉菌毒素——黄曲霉毒素的污染情况。我们还发现了包括赭曲霉毒素A和玉米赤霉烯酮在内的其他霉菌毒素的共同污染。