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Co-contamination of Aflatoxins with Ochratoxin A and Zearalenone in Semen.精液中黄曲霉毒素与赭曲霉毒素A和玉米赤霉烯酮的共污染
Toxicol Res. 2009 Sep;25(3):125-131. doi: 10.5487/TR.2009.25.3.125. Epub 2009 Sep 1.
2
Significance of Mycotoxins to Food Safety and Human Health .霉菌毒素对食品安全和人类健康的重要性 。
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Occurrence of fungi and mycotoxins in herbal medicines and rapid detection of toxin-producing fungi.中草药中的真菌和霉菌毒素的发生以及产毒真菌的快速检测。
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5
Recent mycotoxin survey data and advanced mycotoxin detection techniques reported from China: a review.近期来自中国的霉菌毒素调查数据及先进霉菌毒素检测技术:综述
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Contamination of herbal medicinal products in low-and-middle-income countries: A systematic review.低收入和中等收入国家草药产品的污染:一项系统综述。
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Oxidative Stress in Extrahepatic Tissues of Rats Co-Exposed to Aflatoxin B1 and Low Protein Diet.黄曲霉毒素B1与低蛋白饮食共同暴露的大鼠肝外组织中的氧化应激
Toxicol Res. 2018 Jul;34(3):211-220. doi: 10.5487/TR.2018.34.3.211. Epub 2018 Jul 15.
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Incidence and level of aflatoxins contamination in medicinal plants in Korea.韩国药用植物中黄曲霉毒素的污染发生率及污染水平。
Mycobiology. 2014 Dec;42(4):339-45. doi: 10.5941/MYCO.2014.42.4.339. Epub 2014 Dec 31.

本文引用的文献

1
Effects of Food Processing on Mycotoxins.食品加工对霉菌毒素的影响。
J Food Prot. 1984 Jun;47(6):489-499. doi: 10.4315/0362-028X-47.6.489.
2
Occurrence and daily intake of ochratoxin A of organic and non-organic rice and rice products.有机和非有机大米及大米制品中赭曲霉毒素A的存在情况及每日摄入量。
Int J Food Microbiol. 2006 Mar 15;107(2):223-7. doi: 10.1016/j.ijfoodmicro.2005.10.001. Epub 2005 Nov 28.
3
The effect of substrate on mycotoxin production of selected Penicillium strains.底物对所选青霉菌株产毒的影响。
Int J Food Microbiol. 2005 Mar 15;99(2):207-14. doi: 10.1016/j.ijfoodmicro.2004.08.014.
4
Zearalenone induces chromosome aberrations in mouse bone marrow: preventive effect of 17beta-estradiol, progesterone and Vitamin E.玉米赤霉烯酮诱导小鼠骨髓染色体畸变:17β-雌二醇、孕酮和维生素E的预防作用
Mutat Res. 2005 Jan 3;565(2):139-49. doi: 10.1016/j.mrgentox.2004.10.005.
5
Mycotoxins.霉菌毒素
Clin Microbiol Rev. 2003 Jul;16(3):497-516. doi: 10.1128/CMR.16.3.497-516.2003.
6
Mycotoxin production by Aspergillus, Fusarium and Penicillium species.曲霉属、镰刀菌属和青霉属真菌产生的霉菌毒素。
Int J Food Microbiol. 1998 Sep 8;43(3):141-58. doi: 10.1016/s0168-1605(98)00112-3.
7
Recent studies of mycotoxins.近期霉菌毒素研究。
Symp Ser Soc Appl Microbiol. 1998;27:62S-76S. doi: 10.1046/j.1365-2672.1998.0840s162s.x.
8
Survey of ethnic foods for mycotoxins.民族食品中霉菌毒素的调查。
Food Addit Contam. 1996 Oct;13(7):833-41. doi: 10.1080/02652039609374470.
9
Analysis of naturally occurring mycotoxins in feedstuffs and food.饲料和食品中天然存在的霉菌毒素分析。
J Anim Sci. 1993 Sep;71(9):2563-74. doi: 10.2527/1993.7192563x.
10
Risk assessment of the mycotoxin ochratoxin A.霉菌毒素赭曲霉毒素A的风险评估。
Biomed Environ Sci. 1989 Sep;2(3):179-248.

精液中黄曲霉毒素与赭曲霉毒素A和玉米赤霉烯酮的共污染

Co-contamination of Aflatoxins with Ochratoxin A and Zearalenone in Semen.

作者信息

Cho So Yean, Kang Shin Jung, Jung Joohee, Jeong Byeong Ok, Jeong Choon Sik

机构信息

13Herbal Medicine Evaluation Team, Korea Food & Drug Administration, Seoul, 122-704 Korea.

23College of Pharmacy, Duksung Women's University, Seoul, 132-714 Korea.

出版信息

Toxicol Res. 2009 Sep;25(3):125-131. doi: 10.5487/TR.2009.25.3.125. Epub 2009 Sep 1.

DOI:10.5487/TR.2009.25.3.125
PMID:32038830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7006283/
Abstract

Korea is representative of a country that consumes herbal medicines; most of the herbal medicines circulating in South Korea have been imported from developing countries in Southeast Asia, such as China and Indonesia. Recently, domestic hygiene and safety are issues that have come to the forefront, because herbal medicines currently in circulation could possibly contain contaminants or residues. Furthermore, the appearance or discovery of harmful new species due to environmental and industrial developments is becoming a social problem. Therefore, it may be necessary to consider and investigate these matters on a continual basis. Recently, mycotoxin contaminations in such foods as cereals, nuts, and powdered red pepper have been reported. They have become a problematic issue; the possibility of contamination in herbal medicines has also been considered. Nevertheless, recognition of and research into mycotoxin contamination in herbal medicines has been scarce because herbal medicine is used in only a few nations. In this research, we identified contamination by aflatoxin which is known to be the most potent mutagenic, carcinogenic, and teratoge-nic mycotoxin in Thujae Semen, a herbal medicine. We also found co-contaminations involving other mycotoxins, including ochratoxin A and zeraleanone.

摘要

韩国是草药消费大国的代表;韩国流通的大多数草药都是从中国和印度尼西亚等东南亚发展中国家进口的。最近,国内卫生和安全问题成为了首要问题,因为目前流通的草药可能含有污染物或残留物。此外,由于环境和工业发展导致有害新物种的出现或发现正成为一个社会问题。因此,可能有必要持续考虑和调查这些问题。最近,已有报道称谷物、坚果和辣椒粉等食品中存在霉菌毒素污染。它们已成为一个有问题的问题;草药中污染的可能性也已被考虑在内。然而,由于只有少数国家使用草药,对草药中霉菌毒素污染的认识和研究一直很少。在本研究中,我们鉴定出了在草药侧柏叶中已知最具致突变性、致癌性和致畸性的霉菌毒素——黄曲霉毒素的污染情况。我们还发现了包括赭曲霉毒素A和玉米赤霉烯酮在内的其他霉菌毒素的共同污染。