Department of Endocrinology, Sun Yat-sen Memorial Hospital, Guangzhou, China.
Department of Endocrinology, The Seventh Affiliated Hospital Sun Yat-sen University, Shenzhen, China.
BMJ Open. 2020 Feb 10;10(2):e033991. doi: 10.1136/bmjopen-2019-033991.
Hypogonadism in men is related to the deterioration of general health. However, the association between lipid overaccumulation and ageing-related hypogonadism remains an undetermined concept. We aimed to provide an insight into the possible links between the lipid accumulation product (LAP) and late-onset hypogonadism (LOH).
Sun Yat-sen Memorial Hospital of Sun Yat-sen University.
We included a population sample of 997 subjects aged 40 years or older.
The LAP was calculated by gender-specific equations using waist circumference (WC) and triglyceride (TG). LOH was defined by the presence of androgen deficiency symptoms and low serum total testosterone levels.
The prevalence of LOH was 9.4% in this population and gradually increased according to increasing LAP quartiles. Compared with subjects without LOH, ageing men with LOH had higher body mass index, WC, systolic blood pressure, percentage of subjects currently smoking, TG and follicle stimulating hormone and lower low-density lipoprotein cholesterol and sex hormone binding globulin. In multivariate logistic regression analysis, the adjusted ORs of LOH for increasing LAP quartiles 1-4 were 1.00 (reference), 1.10 (95% CI 0.45-2.69), 2.15 (95% CI 0.93-4.94) and 3.83 (95% CI 1.73-8.45), respectively.
Body lipid accumulation evaluated by the LAP is independently associated with the prevalence of LOH in middle-aged and elderly Chinese men.
男性性腺功能减退与整体健康状况恶化有关。然而，脂质过度堆积与与年龄相关的性腺功能减退之间的关系仍然是一个未确定的概念。我们旨在深入了解脂质蓄积产物（LAP）与迟发性性腺功能减退（LOH）之间可能存在的联系。
中山大学孙逸仙纪念医院。
我们纳入了一个年龄在 40 岁及以上的 997 例人群样本。
使用腰围（WC）和甘油三酯（TG），通过性别特异性方程计算 LAP。LOH 通过雄激素缺乏症状和血清总睾酮水平降低来定义。
在该人群中，LOH 的患病率为 9.4%，并随着 LAP 四分位的增加而逐渐增加。与无 LOH 的男性相比，患有 LOH 的老年男性的体重指数、WC、收缩压、当前吸烟人数百分比、TG 和卵泡刺激素更高，而低密度脂蛋白胆固醇和性激素结合球蛋白更低。在多变量逻辑回归分析中，LAP 四分位 1-4 与 LOH 相关的调整后 OR 值分别为 1.00（参考值）、1.10（95%CI 0.45-2.69）、2.15（95%CI 0.93-4.94）和 3.83（95%CI 1.73-8.45）。
通过 LAP 评估的身体脂肪堆积与中老年中国男性 LOH 的患病率独立相关。
