Khaliq Muhammad F, Noorani Muhammad M, Tariq Syed Maaz, Koirala Ashish, Mohamed Hesham
Internal Medicine, Charleston Area Medical Center, West Virginia University-Charleston Division, Charleston, USA.
Hospital Medicine, Baptist Medical Center South, Montgomery, USA.
Cureus. 2020 Jan 12;12(1):e6634. doi: 10.7759/cureus.6634.
Pulmonary Langerhans cell histiocytosis (PLCH, pulmonary eosinophilic granuloma) is a rare disease of clonal dendritic cells that primarily affects adults who smoke cigarettes. PLCH association with other malignancies is rarely reported. Herein, an unusual case of PLCH is presented with synchronous lung adenocarcinoma. A 76-year-old woman and chronic smoker was admitted for persistent dyspnea and productive cough, and had a left lower lung mass detected by computed tomography. She underwent bronchoscopy with biopsies. Histopathological analysis was negative, but cultures grew Mycobacterium avium complex. She subsequently underwent lobectomy and was found to have papillary adenocarcinoma with PLCH in the surrounding lung nodules.
肺朗格汉斯细胞组织细胞增多症（PLCH，肺嗜酸性肉芽肿）是一种罕见的克隆性树突状细胞疾病，主要影响吸烟的成年人。PLCH与其他恶性肿瘤的关联鲜有报道。在此，报告一例不寻常的PLCH病例，同时合并肺腺癌。一名76岁的老年女性，长期吸烟，因持续性呼吸困难和咳痰入院，计算机断层扫描发现左下肺有一肿块。她接受了支气管镜检查及活检。组织病理学分析结果为阴性，但培养发现鸟分枝杆菌复合群。随后她接受了肺叶切除术，发现为乳头状腺癌，周围肺结节中有PLCH。
