Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77840, USA.
Department of Materials Science and Engineering, Texas A&M University, College Station, TX 77840, USA.
Sensors (Basel). 2020 Feb 17;20(4):1098. doi: 10.3390/s20041098.
For the hundreds of millions of worldwide diabetic patients, glucose test strips are the most important and commonly used tool for monitoring blood glucose levels. Commercial test strips use glucose oxidases as recognition agents, which increases the cost and reduces the durability of test strips. To lower the cost of glucose sensors, we developed a paper-based electrical sensor with molecularly imprinted glucose recognition sites and demonstrated the determination of various glucose concentrations in bovine blood solutions. The sensing electrode is integrated with molecular recognition sites in the conductive polymer. A calibration graph as a function of glucose concentration in aqueous solution was acquired and matched with a correlation coefficient of 0.989. We also demonstrated the determination of the added glucose concentrations ranging from 2.2 to 11.1 mM in bovine blood samples with a linear correlation coefficient of 0.984. This non-enzymatic glucose sensor has the potential to reduce the health care cost of test strips as well as make glucose sensor test strips more accessible to underserved communities.
对于全球数以亿计的糖尿病患者来说，血糖测试条是监测血糖水平的最重要和最常用的工具。商业测试条使用葡萄糖氧化酶作为识别剂，这增加了测试条的成本并降低了其耐用性。为了降低葡萄糖传感器的成本，我们开发了一种基于纸张的电传感器，具有分子印迹的葡萄糖识别位点，并演示了在牛血液溶液中测定各种葡萄糖浓度。传感电极与导电聚合物中的分子识别位点集成在一起。获得了水溶液中葡萄糖浓度的校准曲线，并与相关系数 0.989 相匹配。我们还演示了在牛血液样品中添加的葡萄糖浓度从 2.2 到 11.1 mM 的测定，线性相关系数为 0.984。这种无酶葡萄糖传感器有可能降低测试条的医疗保健成本，并使葡萄糖传感器测试条更容易为服务不足的社区所获得。
