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锌改性羟基磷灰石的合成与性能

Synthesis and Properties of Zinc-Modified Hydroxyapatite.

作者信息

Lytkina Daria, Gutsalova Anastasiya, Fedorishin Dmitriy, Korotchenko Natalya, Akhmedzhanov Rafik, Kozik Vladimir, Kurzina Irina

机构信息

Laboratory of Chemical Technology, National Research Tomsk State University, Lenin 36, 634050 Tomsk, Russia.

Department of Life Safety and Biomedical Disciplines, Tomsk State Pedagogical University, Kievskaya 60, 634061 Tomsk, Russia.

出版信息

J Funct Biomater. 2020 Feb 20;11(1):10. doi: 10.3390/jfb11010010.

Abstract

Hydroxyapatites modified with metal ions are the main inorganic components of bone tissue and are approved for use as components for biocomposites and coatings for surgical implants. This study examined prototypes of functional materials for bone implants based on hydroxyapatite modified with zinc ions. Zinc-modified hydroxyapatite was composed and synthesized. Using the XRD method, the phase composition was established. Using SEM, EPMA, and low-temperature nitrogen adsorption (BET) methods, surface properties were investigated. Antibacterial activity and biocompatibility have been established. The studied materials have antimicrobial activity; the samples did not cause significant changes in either the internal organs or the general condition of laboratory animals during the entire experiment.

摘要

金属离子改性的羟基磷灰石是骨组织的主要无机成分,已被批准用作生物复合材料的组分和外科植入物的涂层。本研究考察了基于锌离子改性羟基磷灰石的骨植入物功能材料原型。制备并合成了锌改性羟基磷灰石。采用XRD方法确定了相组成。利用扫描电子显微镜(SEM)、电子探针微区分析(EPMA)和低温氮吸附(BET)方法研究了表面性质。确定了抗菌活性和生物相容性。所研究的材料具有抗菌活性;在整个实验过程中,样品未对实验动物的内脏器官或总体状况造成显著变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1486/7151590/7e7c481b23d7/jfb-11-00010-g001.jpg

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