非洲人群视网膜神经纤维层厚度和视神经乳头参数的正常参考值及其与视觉功能的关系
Normative Values of Retinal Nerve Fibre Layer Thickness and Optic Nerve Head Parameters and Their Association with Visual Function in an African Population.
作者信息
Ocansey Stephen, Abu Emmanuel Kwasi, Owusu-Ansah Andrew, Mensah Shadrack, Oduro-Boateng John, Kojo Rene Abalo, Kyei Samuel, Boadi-Kusi Samuel Bert, Amoah-Smith Obed, Morny Enyam Komla Amewuho, Darko-Takyi Charles, Abraham Carl Halladay, Appiah Nyamekye Benjamin, Ilechie Alex Azuka
机构信息
Department of Optometry, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Glaucoma Research Group, 2nd Xiangya Hospital of Central South University, Changsha, China.
出版信息
J Ophthalmol. 2020 Feb 11;2020:7150673. doi: 10.1155/2020/7150673. eCollection 2020.
PURPOSE
To determine normative values of retinal nerve fibre layer thickness (RNFL) and optic nerve head (ONH) parameters and their association with routine clinical tests such as refractive error (RE), stereoacuity (SA), and contrast sensitivity (CS) in an African population.
METHODS
In a cross-sectional observational study, 100 normal subjects aged 20 to 78 years were evaluated using the Cirrus HD-OCT 5000 and matched with 200 glaucoma patients.
RESULTS
Average (±SD) RNFL thickness for normal subjects was found to be 102.37 ± 7.45 (range, 82-119 microns) compared with 90.74 ± 14.50 found for glaucoma subjects. Females had higher average RNFL values (104.84 ± 6.90) compared with males (99.80 ± 7.18). Significant associations were calculated between quadrant RNFL thickness and SA, SE, and CS (all < 0.05). The mean cup to disc ratio (CDR) was 0.49 ± 0.12, and mean optic disc area (DA) was 2.08 mm ± 0.40. Smaller DA was recorded for participants aged 60+ years (1.86 ± 0.25), followed by 40-59 age group (2.01 ± 0.41) and then 20-39 age group (2.19 ± 0.41). Significant associations were calculated between SA and ONH parameters, except rim area (all < 0.05). The mean cup to disc ratio (CDR) was 0.49 ± 0.12, and mean optic disc area (DA) was 2.08 mm ± 0.40. Smaller DA was recorded for participants aged 60+ years (1.86 ± 0.25), followed by 40-59 age group (2.01 ± 0.41) and then 20-39 age group (2.19 ± 0.41). Significant associations were calculated between SA and ONH parameters, except rim area (all < 0.05). The mean cup to disc ratio (CDR) was 0.49 ± 0.12, and mean optic disc area (DA) was 2.08 mm ± 0.40. Smaller DA was recorded for participants aged 60+ years (1.86 ± 0.25), followed by 40-59 age group (2.01 ± 0.41) and then 20-39 age group (2.19 ± 0.41). Significant associations were calculated between SA and ONH parameters, except rim area (all.
CONCLUSION
RNFL thickness in healthy black Ghanaian population was significantly higher than that reported in other races. The values and associations reported in this study can inform clinical decision on the normal variation in RNFL and optic disc parameters.
目的
确定非洲人群视网膜神经纤维层厚度（RNFL）和视神经乳头（ONH）参数的标准值，以及它们与屈光不正（RE）、立体视锐度（SA）和对比敏感度（CS）等常规临床检查的相关性。
方法
在一项横断面观察性研究中，使用Cirrus HD-OCT 5000对100名年龄在20至78岁的正常受试者进行评估，并与200名青光眼患者进行匹配。
结果
正常受试者的平均（±标准差）RNFL厚度为102.37±7.45（范围82-119微米），而青光眼受试者为90.74±14.50。女性的平均RNFL值（104.84±6.90）高于男性（99.80±7.18）。象限RNFL厚度与SA、SE和CS之间存在显著相关性（均P<0.05）。平均杯盘比（CDR）为0.49±0.12，平均视盘面积（DA）为2.08平方毫米±0.40。60岁及以上参与者的DA较小（1.86±0.25），其次是40-59岁年龄组（2.01±0.41），然后是20-3q9岁年龄组（2.19±0.41）。SA与ONH参数之间存在显著相关性，但边缘面积除外（均P<0.05）。平均杯盘比（CDR）为0.49±0.12，平均视盘面积（DA）为2.08平方毫米±0.40。60岁及以上参与者的DA较小（1.86±0.25），其次是40-59岁年龄组（2.01±0.41），然后是20-39岁年龄组（2.19±0.41）。SA与ONH参数之间存在显著相关性，但边缘面积除外（均P<0.05）。平均杯盘比（CDR）为0.49±0.12，平均视盘面积（DA）为2.08平方毫米±0.40。60岁及以上参与者的DA较小（1.86±0.25），其次是40-59岁年龄组（2.01±0.41），然后是20-39岁年龄组（2.19±0.41）。SA与ONH参数之间存在显著相关性，但边缘面积除外（均P<0.05）。
结论
健康的加纳黑人人群的RNFL厚度显著高于其他种族报道的值。本研究报告的值和相关性可为RNFL和视盘参数正常变异的临床决策提供参考。
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