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检测唾液和尿液中的奥罗普切病毒。

Oropouche virus detection in saliva and urine.

机构信息

Fundação Oswaldo Cruz-Fiocruz, Instituto Leônidas e Maria Deane, Manaus, AM, Brasil.

Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Programa de Pós-Graduação em Biologia Celular e Molecular, Rio de Janeiro, RJ, Brasil.

出版信息

Mem Inst Oswaldo Cruz. 2020 Feb 27;115:e190338. doi: 10.1590/0074-02760190338. eCollection 2020.

Abstract

Oropouche virus (OROV) is an arthropod-borne virus of the Peribunyaviridae family, transmitted to humans primarily by Culicoides paraensis. It is one of the main arboviruses infecting humans in Brazil, primarily in the Amazon Region. Here, we report the detection of OROV in the saliva and urine of a patient whose samples were collected five days after the onset of symptoms. Nucleotide sequencing and phylogenetic analysis further confirmed the results. To our knowledge, this is the first study reporting the detection of OROV in the saliva and urine of an infected patient. In addition, the results of our study expand the current knowledge pertaining to the natural history of Oropouche fever.

摘要

奥罗普切病毒(OROV)是一种虫媒病毒,属于披膜病毒科,主要通过库蠓属中的库蠓传播给人类。它是巴西主要在亚马逊地区感染人类的主要虫媒病毒之一。在这里,我们报告了在一名患者的唾液和尿液中检测到 OROV,该患者的样本是在症状出现五天后采集的。核苷酸测序和系统进化分析进一步证实了这一结果。据我们所知,这是首例报告在感染患者的唾液和尿液中检测到 OROV 的研究。此外,我们的研究结果扩展了目前对奥罗普切热自然史的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f0/7046135/f67f944c8c41/1678-8060-mioc-115-e190338-gf.jpg

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