Huang Rui, Li Wei, Zhao Ying, Yang Fan, Xu Meng
Department of neurosurgery, The Second Hospital of Jilin University.
Department of pediatrics, The First Hospital of Jilin University.
Medicine (Baltimore). 2020 Mar;99(11):e19434. doi: 10.1097/MD.0000000000019434.
We performed a meta-analysis of the efficacy and safety of stem cell therapy as a clinical treatment of knee osteoarthritis. This meta-analysis is expected to provide evidence of the efficacy of stem cell therapy, which is currently controversial, as a conservative treatment for knee osteoarthritis.
An online search for relevant articles was conducted in the PubMed, EMBASE, and Cochrane Library databases. The search terms were "stem cells" and "osteoarthritis." We conducted a quality assessment of the included articles and extracted the following indicators: Visual Analogue Scale (VAS) score, Subjective International Knee Documentation Committee (IKDC) score, Western Ontario and McMaster Universities (WOMAC) subscales, and adverse events. The RevMan5.3 software was used for determining effect sizes.
Nine randomized controlled trials involving 339 patients were included. VAS score and IKDC score from baseline to 24 months were improved in the stem cell therapy group compared to those in the control group. However, no significant difference was observed between the 2 groups in IKDC score changes from baseline to 6 and 12 months, as well as in WOMAC-Pain, WOMAC-Stiffness, and WOMAC-Physical Function score changes at each visit point.
Stem cell therapy is certainly superior to traditional treatments in the conservative treatment of KOA; it considerably reduces pain with no obvious additional side effects.
我们对干细胞疗法作为膝关节骨关节炎临床治疗方法的疗效和安全性进行了荟萃分析。该荟萃分析旨在为目前存在争议的干细胞疗法作为膝关节骨关节炎保守治疗方法的疗效提供证据。
在PubMed、EMBASE和Cochrane图书馆数据库中进行在线搜索相关文章。检索词为“干细胞”和“骨关节炎”。我们对纳入的文章进行了质量评估，并提取了以下指标：视觉模拟评分（VAS）、主观国际膝关节文献委员会（IKDC）评分、西安大略和麦克马斯特大学（WOMAC）子量表以及不良事件。使用RevMan5.3软件确定效应大小。
纳入了9项涉及339例患者的随机对照试验。与对照组相比，干细胞治疗组从基线到24个月的VAS评分和IKDC评分有所改善。然而，两组在从基线到6个月和12个月的IKDC评分变化以及各访视点的WOMAC疼痛、WOMAC僵硬和WOMAC身体功能评分变化方面均未观察到显著差异。
在膝关节骨关节炎的保守治疗中，干细胞疗法肯定优于传统治疗方法；它能显著减轻疼痛且无明显额外副作用。
