School of Life Sciences and Engineering, Foshan University, Foshan, Guangdong Province, China.
The First Hospital of Jilin University, Changchun, Jilin Province, China.
Curr Opin Virol. 2020 Feb;40:11-18. doi: 10.1016/j.coviro.2020.02.001. Epub 2020 Mar 24.
In the last five years, several novel segmented RNA viruses have been discovered in ticks, mosquitoes, or other arthropods, and two viruses, including Jingmen tick virus and Alongshan virus, are associated with human febrile illness in northeastern China. The viral genome includes four or five segments, two of which are genetically derived from unsegmented flaviviruses. Phylogenetic analysis reveals that segmented flaviviruses belong to a separate Jingmenvirus group distinctive from the genera of Flavivirus, Hepacivirus, Pestivirus, and Pegivirus in the Flaviviridae family. Tick-borne segmented flaviviruses are closely related to mammalian isolates from humans, monkeys and voles, showing their important significance of public health. Future studies should be focused on disease surveillance, epidemiology, animal infection model and reverse genetics of these emerging segmented flaviviruses.
在过去的五年中，在蜱、蚊子或其他节肢动物中发现了几种新型分段 RNA 病毒，其中有两种病毒，包括京门病毒和阿尔山病毒，与中国东北地区的人类发热疾病有关。病毒基因组包括四个或五个片段，其中两个片段在遗传上来源于未分段的黄病毒。系统发育分析表明，分段黄病毒属于黄病毒科的一个单独的京门病毒群，与黄病毒、丙型肝炎病毒、瘟病毒和戊型肝炎病毒属不同。蜱传分段黄病毒与来自人类、猴子和田鼠的哺乳动物分离株密切相关，表明它们对公共卫生具有重要意义。未来的研究应集中在这些新发分段黄病毒的疾病监测、流行病学、动物感染模型和反向遗传学方面。
