肌张力障碍的医学与外科治疗
Medical and Surgical Treatments for Dystonia.
作者信息
Jinnah H A
机构信息
Department of Neurology, Emory University School of Medicine, Suite 6305 Woodruff Memorial Building, Atlanta, GA 30322, USA; Department of Human Genetics, Emory University School of Medicine, Suite 6305 Woodruff Memorial Building, Atlanta, GA 30322, USA.
出版信息
Neurol Clin. 2020 May;38(2):325-348. doi: 10.1016/j.ncl.2020.01.003. Epub 2020 Mar 2.
Abstract
The dystonias are a large and heterogenous group of disorders characterized by excessive muscle contractions leading to abnormal postures and/or repetitive movements. Their clinical manifestations vary widely, and there are many potential causes. Despite the heterogeneity, helpful treatments are available for the vast majority of patients. Symptom-based therapies include oral medications, botulinum toxins, and surgical interventions. For some subtypes of dystonia, specific mechanism-based treatments are available. Advances in understanding the biological basis for many types of dystonia have led to numerous recent clinical trials, so additional treatments are likely to become available in the very near future.
摘要
肌张力障碍是一大类异质性疾病，其特征为肌肉过度收缩，导致异常姿势和/或重复性动作。它们的临床表现差异很大，且有许多潜在病因。尽管存在异质性，但绝大多数患者都有有效的治疗方法。基于症状的治疗方法包括口服药物、肉毒毒素和手术干预。对于某些肌张力障碍亚型，有基于特定机制的治疗方法。在理解多种肌张力障碍生物学基础方面取得的进展引发了近期大量的临床试验，因此在不久的将来可能会有更多治疗方法问世。
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