Ramadan Wijdan H, Sarkis Aline, Aderian Sandrine Sarine, Milane Aline
Department of Pharmacy Practice, School of Pharmacy, Lebanese American University, Byblos, Lebanon.
School of Pharmacy, Lebanese American University, Byblos, Lebanon.
Dose Response. 2020 Apr 7;18(2):1559325820917832. doi: 10.1177/1559325820917832. eCollection 2020 Apr-Jun.
Asthma and chronic obstructive pulmonary disease (COPD) are chronic illnesses of the airways affecting a good number of people in Lebanon and the Middle East. Pressurized metered-dose inhalers (pMDIs) are important drug delivery systems used to treat such pulmonary diseases. Drugs proven to be valuable and effective may fail to act effectively if such inhalers are used incorrectly. The purpose of this study was to assess the technical use of pMDIs by patients with pulmonary diseases presenting to the community pharmacies in Lebanon.
A structured questionnaire was developed to collect data. A total of 601 patients using drugs delivered through pMDIs and presenting to 12 Lebanese community pharmacies were recruited to participate in the research project. The questionnaire items were divided into 3 subscales: subscale 1-assessing the device preparation; subscale 2-investigating the device use; and subscale 3-examining the knowledge and use of spacers. After confirming the reliability and validity of the survey tool, patients' responses were analyzed and compared according to many variables.
Many patients answered inaccurately to questions assessing both the device preparation and use. Around 40% of patients said they do not coordinate the inhalation with pressing the canister down. The mean scores were 1.72 (± 0.73) over 6 and 5.67 (± 1.44) over 7 for subscales 1 and 2, respectively. The mean total score on all questions was 7.39 over 13, with a standard deviation of 1.75. While patients' age did not impact the results, asthmatic, well-educated, male patients had fewer wrong answers when it comes to preparing and using the device ( < .01).
Our study showed that many patients with asthma and COPD might not be properly using their pMDIs. Appropriate inhaler use is crucial for successful pulmonary disease management. As pMDIs are one of the most difficult devices to use, proper and tailored instructions should be given to patients.
哮喘和慢性阻塞性肺疾病(COPD)是影响黎巴嫩和中东众多人群的气道慢性疾病。压力定量吸入器(pMDIs)是用于治疗此类肺部疾病的重要药物输送系统。如果此类吸入器使用不当,经证实有价值且有效的药物可能无法有效发挥作用。本研究的目的是评估黎巴嫩社区药房中患有肺部疾病的患者对pMDIs的技术使用情况。
设计了一份结构化问卷来收集数据。总共招募了601名使用通过pMDIs给药的药物并前往12家黎巴嫩社区药房的患者参与该研究项目。问卷项目分为3个分量表:分量表1 - 评估装置准备;分量表2 - 调查装置使用;分量表3 - 检查储雾罐的知识和使用情况。在确认调查工具的可靠性和有效性后,根据多个变量对患者的回答进行了分析和比较。
许多患者在评估装置准备和使用的问题上回答不准确。约40%的患者表示他们在按压药罐时不会配合吸气。分量表1和2在6分制下的平均得分分别为1.72(±0.73)和7分制下的5.67(±1.44)。所有问题的平均总分在13分制下为7.39,标准差为1.75。虽然患者的年龄对结果没有影响,但哮喘患者、受过良好教育的男性患者在准备和使用装置方面错误回答较少(<.01)。
我们的研究表明,许多哮喘和COPD患者可能没有正确使用他们的pMDIs。正确使用吸入器对于成功管理肺部疾病至关重要。由于pMDIs是最难使用的装置之一,应该给患者提供适当且量身定制的指导。