• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Natverse，一个用于组合和分析神经解剖学数据的多功能工具箱。

The natverse, a versatile toolbox for combining and analysing neuroanatomical data.

机构信息

Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.

Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.

出版信息

Elife. 2020 Apr 14;9:e53350. doi: 10.7554/eLife.53350.

DOI:10.7554/eLife.53350
PMID:32286229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7242028/
Abstract

To analyse neuron data at scale, neuroscientists expend substantial effort reading documentation, installing dependencies and moving between analysis and visualisation environments. To facilitate this, we have developed a suite of interoperable open-source R packages called the natverse. The natverse allows users to read local and remote data, perform popular analyses including visualisation and clustering and graph-theoretic analysis of neuronal branching. Unlike most tools, the natverse enables comparison across many neurons of morphology and connectivity after imaging or co-registration within a common template space. The natverse also enables transformations between different template spaces and imaging modalities. We demonstrate tools that integrate the vast majority of neuroanatomical light microscopy and electron microscopy connectomic datasets. The is an easy-to-use environment for neuroscientists to solve complex, large-scale analysis challenges as well as an open platform to create new code and packages to share with the community.

摘要

为了大规模分析神经元数据，神经科学家在阅读文档、安装依赖项以及在分析和可视化环境之间切换方面花费了大量精力。为了实现这一目标，我们开发了一套名为 natverse 的可互操作的开源 R 包。natverse 允许用户读取本地和远程数据，执行流行的分析，包括可视化和聚类以及神经元分支的图论分析。与大多数工具不同，natverse 能够在成像后或在公共模板空间内进行共配准后，对许多神经元的形态和连接进行比较。natverse 还能够在不同的模板空间和成像模式之间进行转换。我们展示了一些工具，这些工具集成了绝大多数神经解剖学的光学显微镜和电子显微镜连接组数据集。natverse 是神经科学家解决复杂的大规模分析挑战的简单易用的环境，也是创建新代码和包并与社区共享的开放平台。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/a3a3fd90e125/elife-53350-fig8-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/16d1182c3e85/elife-53350-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/2acfe845aa76/elife-53350-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/f7ba9a3fbded/elife-53350-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/e82df95ac170/elife-53350-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/d6518aecf282/elife-53350-fig2-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/6ed94ab90c86/elife-53350-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/f94094d12fb5/elife-53350-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/e0658aee8c37/elife-53350-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/bd2c865a4c89/elife-53350-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/5b54a00737d1/elife-53350-fig4-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/bc5adec652d8/elife-53350-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/de95c8d35cb3/elife-53350-fig5-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/6902995459c0/elife-53350-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/b0981e1a9ac4/elife-53350-fig6-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/9759fc979d26/elife-53350-fig6-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/14559c1de78b/elife-53350-fig6-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/2c87fce26f56/elife-53350-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/2163986e8e9c/elife-53350-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/a3a3fd90e125/elife-53350-fig8-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/16d1182c3e85/elife-53350-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/2acfe845aa76/elife-53350-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/f7ba9a3fbded/elife-53350-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/e82df95ac170/elife-53350-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/d6518aecf282/elife-53350-fig2-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/6ed94ab90c86/elife-53350-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/f94094d12fb5/elife-53350-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/e0658aee8c37/elife-53350-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/bd2c865a4c89/elife-53350-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/5b54a00737d1/elife-53350-fig4-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/bc5adec652d8/elife-53350-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/de95c8d35cb3/elife-53350-fig5-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/6902995459c0/elife-53350-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/b0981e1a9ac4/elife-53350-fig6-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/9759fc979d26/elife-53350-fig6-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/14559c1de78b/elife-53350-fig6-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/2c87fce26f56/elife-53350-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/2163986e8e9c/elife-53350-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1989/7242028/a3a3fd90e125/elife-53350-fig8-figsupp1.jpg

相似文献

1
The natverse, a versatile toolbox for combining and analysing neuroanatomical data.Natverse，一个用于组合和分析神经解剖学数据的多功能工具箱。
Elife. 2020 Apr 14;9:e53350. doi: 10.7554/eLife.53350.
2
Real-time, low-latency closed-loop feedback using markerless posture tracking.使用无标记姿势跟踪的实时、低延迟闭环反馈。
Elife. 2020 Dec 8;9:e61909. doi: 10.7554/eLife.61909.
3
An integrated calcium imaging processing toolbox for the analysis of neuronal population dynamics.用于分析神经元群体动力学的集成钙成像处理工具箱。
PLoS Comput Biol. 2017 Jun 7;13(6):e1005526. doi: 10.1371/journal.pcbi.1005526. eCollection 2017 Jun.
4
Generation, description and storage of dendritic morphology data.树突形态数据的生成、描述与存储。
Philos Trans R Soc Lond B Biol Sci. 2001 Aug 29;356(1412):1131-45. doi: 10.1098/rstb.2001.0905.
5
Accelerating with FlyBrainLab the discovery of the functional logic of the brain in the connectomic and synaptomic era.在连接组学和突触组学时代，借助 FlyBrainLab 加速大脑功能逻辑的发现。
Elife. 2021 Feb 22;10:e62362. doi: 10.7554/eLife.62362.
6
Quantitative neuroanatomy for connectomics in Drosophila.果蝇连接组学的定量神经解剖学
Elife. 2016 Mar 18;5:e12059. doi: 10.7554/eLife.12059.
7
FlyWire: online community for whole-brain connectomics.FlyWire：全脑连接组学在线社区。
Nat Methods. 2022 Jan;19(1):119-128. doi: 10.1038/s41592-021-01330-0. Epub 2021 Dec 23.
8
A connectome and analysis of the adult central brain.一个成年中枢大脑的连接组和分析。
Elife. 2020 Sep 7;9:e57443. doi: 10.7554/eLife.57443.
9
A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster.成年黑腹果蝇大脑的完整电子显微镜体积。
Cell. 2018 Jul 26;174(3):730-743.e22. doi: 10.1016/j.cell.2018.06.019. Epub 2018 Jul 19.
10
Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing.基于狂犬病病毒的条形码神经解剖学通过单细胞RNA和原位测序得以解析。
Elife. 2024 Feb 6;12:RP87866. doi: 10.7554/eLife.87866.

引用本文的文献

1
Whole-body connectome of a segmented annelid larva.分段环节动物幼虫的全身连接组
Elife. 2025 Aug 27;13:RP97964. doi: 10.7554/eLife.97964.
2
Distributed control circuits across a brain-and-cord connectome.遍布脑脊髓连接组的分布式控制电路。
bioRxiv. 2025 Aug 2:2025.07.31.667571. doi: 10.1101/2025.07.31.667571.
3
Eye structure shapes neuron function in Drosophila motion vision.果蝇运动视觉中的眼睛结构塑造神经元功能。

本文引用的文献

1
Print: An open access tool for EM connectomics.Print：一种用于电子显微镜连接组学的开放获取工具。
Front Neuroinform. 2022 Jul 20;16:896292. doi: 10.3389/fninf.2022.896292. eCollection 2022.
2
An unbiased template of the Drosophila brain and ventral nerve cord.果蝇大脑和腹神经索的无偏模板。
PLoS One. 2020 Dec 31;15(12):e0236495. doi: 10.1371/journal.pone.0236495. eCollection 2020.
3
Auditory activity is diverse and widespread throughout the central brain of Drosophila.听觉活动在果蝇的中枢大脑中是多样且广泛存在的。
Nature. 2025 Jul 23. doi: 10.1038/s41586-025-09276-5.
4
Neural circuit mechanisms for steering control in walking .行走中转向控制的神经回路机制
Elife. 2025 Jul 21;13:RP102230. doi: 10.7554/eLife.102230.
5
Divergent synaptic dynamics originate parallel pathways for computation and behavior in an olfactory circuit.不同的突触动力学在嗅觉回路中产生用于计算和行为的平行通路。
Curr Biol. 2025 Jul 7;35(13):3146-3162.e8. doi: 10.1016/j.cub.2025.05.051. Epub 2025 Jun 19.
6
A comprehensive mechanosensory connectome reveals a somatotopically organized neural circuit architecture controlling stimulus-aimed grooming of the head.一个全面的机械感觉连接体揭示了一种躯体感觉拓扑组织的神经回路结构，该结构控制针对头部刺激的梳理行为。
bioRxiv. 2025 Jun 25:2025.05.19.654894. doi: 10.1101/2025.05.19.654894.
7
Expression of clock genes tracks daily and tidal time in brains of intertidal crustaceans Eurydice pulchra and Parhyale hawaiensis.潮汐带甲壳动物美丽欧氏蜾蠃蜚和夏威夷半海萤大脑中生物钟基因的表达跟踪每日和潮汐时间。
Curr Biol. 2025 Jun 23;35(12):2802-2815.e5. doi: 10.1016/j.cub.2025.04.047. Epub 2025 May 8.
8
A competitive disinhibitory network for robust optic flow processing in Drosophila.果蝇中用于稳健光流处理的竞争性去抑制网络。
Nat Neurosci. 2025 May 1. doi: 10.1038/s41593-025-01948-9.
9
Comparative connectomics of Drosophila descending and ascending neurons.果蝇下行和上行神经元的比较连接组学
Nature. 2025 Apr 30. doi: 10.1038/s41586-025-08925-z.
10
Inhibitory control explains locomotor statistics in walking .抑制性控制解释了步行中的运动统计数据。
Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2407626122. doi: 10.1073/pnas.2407626122. Epub 2025 Apr 17.
Nat Neurosci. 2021 Jan;24(1):93-104. doi: 10.1038/s41593-020-00743-y. Epub 2020 Nov 23.
4
A connectome and analysis of the adult central brain.一个成年中枢大脑的连接组和分析。
Elife. 2020 Sep 7;9:e57443. doi: 10.7554/eLife.57443.
5
Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain.完整的果蝇大脑嗅球投射神经元连接组重构
Curr Biol. 2020 Aug 17;30(16):3183-3199.e6. doi: 10.1016/j.cub.2020.06.042. Epub 2020 Jul 2.
6
Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain.重建 1000 个投射神经元揭示了小鼠大脑中的新细胞类型和长程连接的组织方式。
Cell. 2019 Sep 19;179(1):268-281.e13. doi: 10.1016/j.cell.2019.07.042. Epub 2019 Sep 5.
7
A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila.饥饿果蝇的神经回路在坚持和退缩之间进行仲裁。
Neuron. 2019 Nov 6;104(3):544-558.e6. doi: 10.1016/j.neuron.2019.07.028. Epub 2019 Aug 27.
8
The Fly Brain Atlas.《果蝇大脑图谱》。
Annu Rev Cell Dev Biol. 2019 Oct 6;35:637-653. doi: 10.1146/annurev-cellbio-100818-125444. Epub 2019 Jul 8.
9
Whole-animal connectomes of both Caenorhabditis elegans sexes.雌雄同体秀丽隐杆线虫的全动物连接组图谱。
Nature. 2019 Jul;571(7763):63-71. doi: 10.1038/s41586-019-1352-7. Epub 2019 Jul 3.
10
Quantifying How Staining Methods Bias Measurements of Neuron Morphologies.量化染色方法如何影响神经元形态测量结果的偏差
Front Neuroinform. 2019 May 21;13:36. doi: 10.3389/fninf.2019.00036. eCollection 2019.