Choi Yoojin, Hwang Ji Hyeon, Lee Sang Yup
Metabolic and Biomolecular Engineering National Research Laboratory Department of Chemical and Biomolecular Engineering (BK21 Plus Program), and Institute for the BioCentury Korea Advanced Institute of Science and Technology 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea.
Small Methods. 2018 Apr 10;2(4):1700351. doi: 10.1002/smtd.201700351. Epub 2018 Mar 8.
Rapid, sensitive, selective, convenient, and cost-effective pathogen diagnosis is important to prevent further spread of pandemic diseases, minimize social and economic losses, and to facilitate right clinical therapy. Over the past few years, various sensor-based diagnostic systems outperforming conventional pathogenic diagnostic assays have been developed. Among them, colorimetric biosensors detecting target molecules by the naked eye have attracted much attention due to their simplicity, practicality, and cost-effectiveness. Recently, nanomaterials have been adopted as a versatile signal transduction and amplification tool for rapid and sensitive detection of pathogenic bacteria and viruses. Here, recent trends and advances are reviewed in detecting and diagnosing pathogenic bacteria and viruses using colorimetric biosensors employing various nanomaterials. In addition, it is discussed how nanomaterials and bioreceptors can be better integrated together to develop rapid and sensitive colorimetric detection system in the future.
快速、灵敏、特异、便捷且经济高效的病原体诊断对于防止大流行疾病的进一步传播、将社会和经济损失降至最低以及促进正确的临床治疗至关重要。在过去几年中，已开发出各种优于传统病原诊断检测方法的基于传感器的诊断系统。其中，通过肉眼检测目标分子的比色生物传感器因其简单性、实用性和成本效益而备受关注。最近，纳米材料已被用作一种通用的信号转导和放大工具，用于快速、灵敏地检测病原菌和病毒。在此，本文综述了使用采用各种纳米材料的比色生物传感器检测和诊断病原菌和病毒的最新趋势和进展。此外，还讨论了未来如何更好地将纳米材料和生物受体整合在一起，以开发快速、灵敏的比色检测系统。
