闭环、电机驱动耳迷走神经刺激 (MAAVNS) 系统用于神经康复的设计与验证。
Design and validation of a closed-loop, motor-activated auricular vagus nerve stimulation (MAAVNS) system for neurorehabilitation.
机构信息
Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, USA.
Department of Biomedical Engineering, City College of New York, USA.
出版信息
Brain Stimul. 2020 May-Jun;13(3):800-803. doi: 10.1016/j.brs.2020.02.028. Epub 2020 Feb 27.
BACKGROUND
Studies have found that pairing vagus nerve stimulation (VNS) with motor activity accelerates cortical reorganization. This synchronous pairing may enhance motor recovery.
OBJECTIVE
To develop and validate a motor-activated auricular vagus nerve stimulation (MAAVNS) system as a potential neurorehabilitation tool.
METHODS
We created MAAVNS and validated its function as part of an ongoing clinical trial investigating whether taVNS-paired rehabilitation enhances oromotor learning. We compared 3 different MAAVNS EMG electrode configurations in 3 neonates. The active lead was placed over the buccinator muscle. Reference lead placements were orbital, temporal or frontal.
RESULTS
The frontal reference lead produced the highest sensitivity (0.87 ± 0.07 (n = 8)) and specificity (0.64 ± 0.13 (n = 8)). Oral sucking reliably triggers MAAVNS stimulation with high confidence.
CONCLUSION
EMG electrodes placed on target orofacial muscles can effectively trigger taVNS stimuli in infants in a closed loop fashion.
背景
研究发现，迷走神经刺激（VNS）与运动活动相结合可以加速皮质重组。这种同步配对可能会增强运动恢复。
目的
开发和验证一种运动激活耳迷走神经刺激（MAAVNS）系统，作为一种潜在的神经康复工具。
方法
我们创建了 MAAVNS，并验证了其功能，这是一项正在进行的临床试验的一部分，该试验旨在研究 taVNS 配对康复是否能增强口腔运动学习。我们在 3 名新生儿中比较了 3 种不同的 MAAVNS 肌电图电极配置。主动导联放置在颊肌上。参考导联的放置位置为眶内、颞部或额部。
结果
额部参考导联的灵敏度最高（0.87±0.07（n=8）），特异性也最高（0.64±0.13（n=8））。口腔吸吮能可靠地触发 MAAVNS 刺激，具有很高的可信度。
结论
放置在目标口面肌肉上的肌电图电极可以以闭环方式有效地触发婴儿的 taVNS 刺激。
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