Alghamdi Faisal, Shakir Marwa
Oral Biology, King Abdulaziz University, Jeddah, SAU.
Endodontics, King Abdulaziz University, Jeddah, SAU.
Cureus. 2020 Mar 13;12(3):e7257. doi: 10.7759/cureus.7257.
Endodontic treatment failure may occur due to different causes such as persistence of bacteria, root canals that are poorly cleaned and obturated, improper coronal seal (leakage), and untreated canals (missed canals). The main reason for endodontic failure is the presence of some species of bacteria inside the root canal system such as Enterococcus (E.) faecalis. Those bacteria are more resistant to disinfection agents, causing a persistent intra-radicular or extra-radicular infection. The current review aims to compile all the current studies concerning Enterococcus faecalis as a dental root canal pathogen that causes endodontic failure. In this systemic review, two databases, PubMed and Google Scholar, were searched using specific inclusion and exclusion criteria. Among 2943 studies, only 11 met the inclusion criteria and were included in the review for further analysis. The 11 studies give prominence to the high distribution of Enterococcus faecalis within the root canal system. These studies investigated different aspects of Enterococcus faecalis, including its prevalence, resistance mechanisms, characteristics, express survival genes, and treatment. The compiled data observed that most of the studies highlight Enterococcus faecalis as the primary pathogen associated with endodontic treatment. It has characteristic proprieties that make it capable of escaping disinfection means. Furthermore, clinical trials are required to examine E. faecalis and may provide valuable information about novel microbial detection methods to decrease the number of E. faecalis within the root canal system.
根管治疗失败可能由多种不同原因引起，如细菌残留、根管清理和充填不佳、冠部封闭不当（渗漏）以及未处理的根管（遗漏根管）。根管治疗失败的主要原因是根管系统内存在某些细菌种类，如粪肠球菌。这些细菌对消毒剂更具抗性，会导致根管内或根管外持续感染。本综述旨在汇总目前所有关于粪肠球菌作为导致根管治疗失败的牙根管病原体的研究。在这项系统评价中，使用特定的纳入和排除标准对两个数据库，即PubMed和谷歌学术进行了检索。在2943项研究中，只有11项符合纳入标准并被纳入综述进行进一步分析。这11项研究突出了粪肠球菌在根管系统中的高分布情况。这些研究调查了粪肠球菌的不同方面，包括其患病率、耐药机制、特征、表达存活基因以及治疗方法。汇总的数据表明，大多数研究强调粪肠球菌是与根管治疗相关的主要病原体。它具有使其能够逃避消毒手段的特性。此外，需要进行临床试验来检测粪肠球菌，并可能提供有关新型微生物检测方法的有价值信息，以减少根管系统内粪肠球菌的数量。
