一氧化氮从脂质体的控释。
Controlled release of nitric oxide from liposomes.
作者信息
Suchyta Dakota J, Schoenfisch Mark H
机构信息
Department of Chemistry, The University of North Carolina at Chapel Hill, 131 South Rd., Chapel Hill, North Carolina, 27599.
出版信息
ACS Biomater Sci Eng. 2017 Sep 11;3(9):2136-2143. doi: 10.1021/acsbiomaterials.7b00255. Epub 2017 Jul 3.
Abstract
We report the ability to readily tune NO release from -diazeniumdiolate-encapsulated liposomal structures by altering the NO donor molecule structure and/or phospholipid composition (independently or in combination). While encapsulating more stable NO donors expectedly enhanced the NO release (up to 48 h) from the liposomes, the phospholipid headgroup surface area proved equally useful in controlling NO-release kinetics by influencing the water uptake and concomitant -diazeniumdiolate NO donor breakdown (to NO). The potential therapeutic utility of the NO-releasing liposomes was further assessed in biological/proteinaceous fluids. The NO-release kinetics were similar in buffer and serum.
摘要
我们报告了通过改变一氧化氮供体分子结构和/或磷脂组成（单独或组合）来轻松调节包封重氮二醇盐的脂质体结构中一氧化氮释放的能力。虽然包封更稳定的一氧化氮供体预期会增强脂质体中的一氧化氮释放（长达48小时），但磷脂头部基团表面积在通过影响水摄取和伴随的重氮二醇盐一氧化氮供体分解（生成一氧化氮）来控制一氧化氮释放动力学方面同样有用。在生物/蛋白质流体中进一步评估了释放一氧化氮的脂质体的潜在治疗效用。一氧化氮在缓冲液和血清中的释放动力学相似。
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