金属化：生物无机化学中大自然的挑战。
Metalation: nature's challenge in bioinorganic chemistry.
作者信息
Robinson Nigel J, Glasfeld Arthur
机构信息
Department of Bioscience and Department of Chemistry, University of Durham, Durham, UK.
Chemistry Department, Division of Mathematical and Natural Sciences, Reed College, Oregon, USA.
出版信息
J Biol Inorg Chem. 2020 Jun;25(4):543-545. doi: 10.1007/s00775-020-01790-3. Epub 2020 Apr 24.
Abstract
The association of proteins with metals, metalation, is challenging because the tightest binding metals are rarely the correct ones. Inside cells, correct metalation is enabled by controlled bioavailability plus extra mechanisms for tricky combinations such as iron and manganese.
摘要
蛋白质与金属的结合，即金属化，颇具挑战性，因为结合最紧密的金属往往并非正确的金属。在细胞内部，通过控制生物可利用性以及针对铁和锰等复杂组合的额外机制，可实现正确的金属化。
Zotero 插件