Department of Poultry Science, Mississippi State University, Starkville, MS, USA.
Department of Poultry Science, University of Georgia, Athens, GA, USA.
Poult Sci. 2020 May;99(5):2645-2649. doi: 10.1016/j.psj.2019.12.037. Epub 2020 Mar 12.
Feed additives can be alternatives to antibiotics for routinely encountered pathogens in the poultry production. The objective of this study was to understand effects of organic acid mixture on growth parameters and Salmonella Typhimurium (ST) colonization in broilers. Organic acid mixture is a feed-grade buffered formic acid and sodium formate mixture (Amasil NA). A total of 800 1-day-old Cobb500 males were fed one of the five dietary treatments: a negative control diet without ST challenge (NC), positive control diet with ST challenge (PC), 0.3% organic acid mixture with ST, 0.6% organic acid mixture with ST, and 0.9% organic acid mixture with ST. Treatments were assigned to 20 pens with 40 chicks/pen and 4 replicates of each treatment. Chickens were challenged with 10 CFU/mL of nalidixic acid-resistant ST (ST) 4-D posthatch. In the grower phase, feed conversion rate was significantly reduced in the 9% organic acid mixture compared with the PC. The body weight and body weight gain (BWG) were not affected either in the starter or grower phases. However, in the finisher phase, the nonchallenged NC had higher BWG than the PC (P < 0.05), whereas there were no differences in BWG among the NC and organic acid mixture fed groups. In addition, there was a significant effect of organic acid mixture on the colonization of cecal ST. At 9 dpi, cecal ST was 3.28 log in the PC that was reduced to 2.65 log at 0.3%, 1.40 log at 0.6%, and 0.84 log in 0.9% organic acid mixture. At 24 dpi, cecal ST recovery was 0.81, 0.99, 0.53, and 0.33 log in the PC and 0.3, 0.6, and 0.9% organic acid mixture, respectively. Similarly, at 38 dpi, cecal ST was 0.26, 0.11, 0.33, and 0 log in the PC, 0.3, 0.6, and 0.9%, respectively. These results show that organic acid mixture can be one dietary strategy to control ST infection and maintain efficient growth performance.
在禽类生产中，饲料添加剂可以替代常规遇到的病原体的抗生素。本研究的目的是了解有机酸混合物对生长参数和肠炎沙门氏菌（ST）在肉鸡中的定植的影响。有机酸混合物是一种饲料级缓冲甲酸和甲酸钠混合物（Amasil NA）。总共 800 只 1 日龄的科布 500 雄性小鸡被喂食五种饮食处理中的一种：没有 ST 挑战的负对照饮食（NC）、有 ST 挑战的正对照饮食（PC）、0.3%有机酸混合物与 ST、0.6%有机酸混合物与 ST 和 0.9%有机酸混合物与 ST。处理被分配到 20 个鸡舍，每个鸡舍有 40 只小鸡/舍，每个处理有 4 个重复。小鸡在孵化后用 10 CFU/mL 耐萘啶酸的 ST（ST）4-D 进行攻毒。在生长期，与 PC 相比，9%的有机酸混合物的饲料转化率显著降低。在起始阶段和生长期，体重和体重增加（BWG）都没有受到影响。然而，在育肥期，未攻毒的 NC 的 BWG 高于 PC（P < 0.05），而 NC 和有机酸混合物喂养组之间的 BWG 没有差异。此外，有机酸混合物对盲肠 ST 的定植有显著影响。在 9dpi 时，PC 中的盲肠 ST 为 3.28 log，降至 0.3%时为 2.65 log，降至 0.6%时为 1.40 log，降至 0.9%时为 0.84 log。在 24dpi 时，盲肠 ST 的恢复分别为 PC 中的 0.81、0.99、0.53 和 0.33 log，0.3%、0.6%和 0.9%的有机酸混合物中为 0.99、0.53 和 0.33 log。同样，在 38dpi 时，PC 中的盲肠 ST 分别为 0.26、0.11、0.33 和 0 log，0.3%、0.6%和 0.9%的有机酸混合物中分别为 0.26、0.11、0.33 和 0 log。这些结果表明，有机酸混合物可以作为控制 ST 感染和维持高效生长性能的一种饮食策略。
