间充质干细胞（MSC）分泌组：一种治疗重症 COVID-19 患者的潜在治疗策略。
Mesenchymal stem cell (MSc) secretome: A possible therapeutic strategy for intensive-care COVID-19 patients.
机构信息
São Paulo State Univ UNESP, Botucatu Medical School, Blood Transfusion Center, Cell Engineering Lab, Botucatu, SP, Brazil.
São Paulo State Univ UNESP, Botucatu Medical School, Blood Transfusion Center, Cell Engineering Lab, Botucatu, SP, Brazil.
出版信息
Med Hypotheses. 2020 Sep;142:109769. doi: 10.1016/j.mehy.2020.109769. Epub 2020 Apr 25.
Abstract
As an emerging global health challenge, COVID-19 requires international knowledge to reach novel possible therapeutic strategies, especially for intensive-care patients. During the early stages of infection, pneumocytes II are the primary infected cells, harming the respiratory system. We have previous evidence in murine models that MSc's secretome can be used to treat pulmonary injuries induced with bleomycin, due to its content: growth factors, extracellular vesicles, and exosomes. We hypothesize and strongly recommend MSc secretome testing and production, in xenofree conditions, to be used as an alternative approach in SARS-Cov-2 patients in critical conditions.
摘要
作为一个新兴的全球健康挑战，COVID-19 需要国际知识来寻找新的可能的治疗策略，特别是对重症监护患者。在感染的早期阶段，II 型肺泡细胞是主要的感染细胞，会损害呼吸系统。我们之前在小鼠模型中已经有证据表明，间充质干细胞的分泌组可以用于治疗博来霉素诱导的肺损伤，这是由于其内容物：生长因子、细胞外囊泡和外泌体。我们假设并强烈建议在无异种条件下测试和生产间充质干细胞分泌组，并将其作为危重症 SARS-Cov-2 患者的一种替代治疗方法。
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