Kong Zhaohong, Wang Jingwei, Li Tao, Zhang Zhaohui, Jian Jiang
Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Department of Medical Molecular Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Ann Transl Med. 2020 Apr;8(7):506. doi: 10.21037/atm.2020.03.89.
The 2019 novel coronavirus (2019-nCoV) epidemic continues, with the number of infections and deaths increasing. The respiratory tract is the main route of transmission of the virus, and the majority of symptoms are respiratory relative. Until now, there has been no reports concerning the nervous system onset. We present a 2019-nCoV patient with the onset of simple dizziness, accompanied by dry throat, no fever, no cough, no headache, no mental abnormality, and no obvious abnormality in the nuclear magnetic resonance imaging (MRI) of the head. Meanwhile, chest computed tomography (CT) scans showed multiple small spot shadows and interstitial changes in the early stage, especially in the extrapulmonary zone. There was a development of multiple ground-glass shadows and infiltrative shadows in both lungs with mild pleural effusion. The nucleic acid gene detection was positive, and thus the diagnosis of 2019-nCoV was confirmed. At last, the prognosis was good after active treatment. After antiviral and anti-infective treatment, the symptoms recovered. We presume that 2019-nCoV can also manifest in the nervous system alone, and lung CT, which has relative specificity, should be used as a routine screening method.
2019新型冠状病毒(2019-nCoV)疫情仍在持续,感染人数和死亡人数不断增加。呼吸道是该病毒的主要传播途径,多数症状与呼吸道相关。截至目前,尚无关于神经系统发病的报道。我们报告1例以单纯头晕起病的2019-nCoV患者,伴有咽干,无发热、咳嗽、头痛、精神异常,头部核磁共振成像(MRI)无明显异常。同时,胸部计算机断层扫描(CT)早期显示多发小斑片状阴影及间质改变,尤其是肺外带。双肺出现多发磨玻璃影及浸润影,伴有少量胸腔积液。核酸基因检测呈阳性,确诊为2019-nCoV感染。经积极治疗后,预后良好。经过抗病毒及抗感染治疗,症状得以恢复。我们推测2019-nCoV也可单独累及神经系统,具有相对特异性的肺部CT应作为常规筛查手段。